Reference - Detail
| RRC ID | 31386 |
|---|---|
| Author | Tsuda M, Ootaka R, Ohkura C, Kishita Y, Seong KH, Matsuo T, Aigaki T. |
| Title | Loss of Trx-2 enhances oxidative stress-dependent phenotypes in Drosophila. |
| Journal | FEBS Lett |
| Abstract |
Overexpression of thioredoxin (TRX) confers oxidative stress resistance and extends lifespan in mammals and insects. However, less is known about phenotypes associated with loss of TRX. We investigated loss-of-function phenotypes of Trx-2 in Drosophila, and found that the mutant flies are hyper-susceptible to paraquat, a free radical generator, but not to hydrogen peroxide. They contain a high amount of protein carbonyl, which dramatically increases with age. Trx-2 mutants express high levels of anti-oxidant genes, such as superoxide dismutase, catalase, and glutathione synthetase. This is the first demonstration of biochemical and physiological consequences caused by loss of Trx-2 in Drosophila. |
| Volume | 584(15) |
| Pages | 3398-401 |
| Published | 2010-8-4 |
| DOI | 10.1016/j.febslet.2010.06.034 |
| PII | S0014-5793(10)00529-6 |
| PMID | 20600005 |
| MeSH | Animals Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / drug effects Drosophila melanogaster / genetics Drosophila melanogaster / metabolism* Gene Expression Regulation / drug effects Insecticide Resistance / drug effects Insecticide Resistance / genetics Longevity / drug effects Motor Activity / drug effects Mutation / genetics Oxidants / metabolism Oxidative Stress* / drug effects Oxidative Stress* / genetics Paraquat / toxicity Phenotype Protein Carbonylation / drug effects Thioredoxins / genetics Thioredoxins / metabolism* |
| IF | 3.057 |
| Times Cited | 26 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| Drosophila | |