RRC ID 31750
Author Brennecke J, Hipfner DR, Stark A, Russell RB, Cohen SM.
Title bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila.
Journal Cell
Abstract Cell proliferation, cell death, and pattern formation are coordinated in animal development. Although many proteins that control cell proliferation and apoptosis have been identified, the means by which these effectors are linked to the patterning machinery remain poorly understood. Here, we report that the bantam gene of Drosophila encodes a 21 nucleotide microRNA that promotes tissue growth. bantam expression is temporally and spatially regulated in response to patterning cues. bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity.
Volume 113(1)
Pages 25-36
Published 2003-4-4
DOI 10.1016/s0092-8674(03)00231-9
PII S0092867403002319
PMID 12679032
MeSH 3' Untranslated Regions / genetics Animals Apoptosis / genetics* Base Sequence / genetics Cell Division / genetics* Chromosome Mapping Cyclins / genetics* Drosophila Proteins / genetics* Drosophila melanogaster / embryology* Drosophila melanogaster / genetics Drosophila melanogaster / metabolism Gene Expression Regulation, Developmental / genetics Genes, Regulator / genetics Larva / genetics Larva / growth & development MicroRNAs / genetics* Molecular Sequence Data Mutation / genetics Neuropeptides / genetics* Proto-Oncogene Proteins / genetics Repressor Proteins / genetics Wnt1 Protein
IF 38.637
Times Cited 1494