RRC ID 32452
Author Yamanaka N, Romero NM, Martin FA, Rewitz KF, Sun M, O'Connor MB, Léopold P.
Title Neuroendocrine control of Drosophila larval light preference.
Journal Science
Abstract Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors--the Bolwig's organ and the peripheral class IV dendritic arborization neurons--to regulate light avoidance. We found that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, driving animals toward a darker environment to initiate the immobile maturation phase. Thus, PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development.
Volume 341(6150)
Pages 1113-6
Published 2013-9-6
DOI 10.1126/science.1241210
PII 341/6150/1113
PMID 24009394
PMC PMC3906047
MeSH Animals Darkness Drosophila Proteins / agonists Drosophila Proteins / genetics Drosophila melanogaster / growth & development* Enzyme Activation Escape Reaction* Insect Hormones / genetics Insect Hormones / physiology* Larva / growth & development Light* Light Signal Transduction* Neurons / physiology* Neurosecretory Systems / physiology* RNA Interference Receptor Protein-Tyrosine Kinases / agonists Receptor Protein-Tyrosine Kinases / genetics
IF 41.063
Times Cited 54
Drosophila DGRC#103604 DGRC#103614 DGRC#113244