論文 - 詳細
| RRC ID | 32452 |
|---|---|
| 著者 | Yamanaka N, Romero NM, Martin FA, Rewitz KF, Sun M, O'Connor MB, Léopold P. |
| タイトル | Neuroendocrine control of Drosophila larval light preference. |
| ジャーナル | Science |
| Abstract |
Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors--the Bolwig's organ and the peripheral class IV dendritic arborization neurons--to regulate light avoidance. We found that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, driving animals toward a darker environment to initiate the immobile maturation phase. Thus, PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development. |
| 巻・号 | 341(6150) |
| ページ | 1113-6 |
| 公開日 | 2013-9-6 |
| DOI | 10.1126/science.1241210 |
| PII | 341/6150/1113 |
| PMID | 24009394 |
| PMC | PMC3906047 |
| MeSH | Animals Darkness Drosophila Proteins / agonists Drosophila Proteins / genetics Drosophila melanogaster / growth & development* Enzyme Activation Escape Reaction* Insect Hormones / genetics Insect Hormones / physiology* Larva / growth & development Light* Light Signal Transduction* Neurons / physiology* Neurosecretory Systems / physiology* RNA Interference Receptor Protein-Tyrosine Kinases / agonists Receptor Protein-Tyrosine Kinases / genetics |
| IF | 41.846 |
| 引用数 | 54 |
| WOS 分野 | NEUROSCIENCES |
| リソース情報 | |
| ショウジョウバエ | DGRC#103604 DGRC#103614 DGRC#113244 |