Reference - Detail
RRC ID | 32452 |
---|---|
Author | Yamanaka N, Romero NM, Martin FA, Rewitz KF, Sun M, O'Connor MB, Léopold P. |
Title | Neuroendocrine control of Drosophila larval light preference. |
Journal | Science |
Abstract |
Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors--the Bolwig's organ and the peripheral class IV dendritic arborization neurons--to regulate light avoidance. We found that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, driving animals toward a darker environment to initiate the immobile maturation phase. Thus, PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development. |
Volume | 341(6150) |
Pages | 1113-6 |
Published | 2013-9-6 |
DOI | 10.1126/science.1241210 |
PII | 341/6150/1113 |
PMID | 24009394 |
PMC | PMC3906047 |
MeSH | Animals Darkness Drosophila Proteins / agonists Drosophila Proteins / genetics Drosophila melanogaster / growth & development* Enzyme Activation Escape Reaction* Insect Hormones / genetics Insect Hormones / physiology* Larva / growth & development Light* Light Signal Transduction* Neurons / physiology* Neurosecretory Systems / physiology* RNA Interference Receptor Protein-Tyrosine Kinases / agonists Receptor Protein-Tyrosine Kinases / genetics |
IF | 41.846 |
Times Cited | 54 |
WOS Category | NEUROSCIENCES |
Resource | |
Drosophila | DGRC#103604 DGRC#103614 DGRC#113244 |