論文 - 詳細
| RRC ID | 32505 |
|---|---|
| 著者 | Moskalev A, Plyusnina E, Shaposhnikov M, Shilova L, Kazachenok A, Zhavoronkov A. |
| タイトル | The role of D-GADD45 in oxidative, thermal and genotoxic stress resistance. |
| ジャーナル | Cell Cycle |
| Abstract |
There is a relationship between various cellular stress factors and aging. In earlier studies, we demonstrated that overexpression of the D-GADD45 gene increases the life span of Drosophila melanogaster. In this study, we investigate the relationship between D-GADD45 activity and resistance to oxidative, genotoxic and thermal stresses as well as starvation. In most cases, flies with constitutive and conditional D-GADD45 overexpression in the nervous system were more stress-resistant than ones without overexpression. At the same time, most of the studied stress factors increased D-GADD45 expression in the wild-type strain. The lifespan-extending effect of D-GADD45 overexpression was also retained after exposure to chronic and acute gamma-irradiation, with doses of 40 сGy and 30 Gy, respectively. However, knocking out D-GADD45 resulted in a significant reduction in lifespan, lack of radiation hormesis and radioadaptive response. A dramatic decrease in the spontaneous level of D-GADD45 expression was observed in the nervous system as age progressed, which may be one of the causes of the age-related deterioration of organismal stress resistance. Thus, D-GADD45 expression is activated by most of the studied stress factors, and D-GADD45 overexpression resulted in an increase of stress resistance. |
| 巻・号 | 11(22) |
| ページ | 4222-41 |
| 公開日 | 2012-11-15 |
| DOI | 10.4161/cc.22545 |
| PII | 22545 |
| PMID | 23095639 |
| PMC | PMC3524218 |
| MeSH | Animals Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / metabolism Drug Resistance Female Gamma Rays* Genotype Herbicides / toxicity* Hormesis Intracellular Signaling Peptides and Proteins / genetics Intracellular Signaling Peptides and Proteins / metabolism* Longevity Male Mutation Nervous System / metabolism Oxidative Stress / drug effects* Paraquat / toxicity Starvation Temperature |
| IF | 3.699 |
| 引用数 | 24 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#112149 |