RRC ID 32550
Author Shang Y, Donelson NC, Vecsey CG, Guo F, Rosbash M, Griffith LC.
Title Short neuropeptide F is a sleep-promoting inhibitory modulator.
Journal Neuron
Abstract To advance the understanding of sleep regulation, we screened for sleep-promoting cells and identified neurons expressing neuropeptide Y-like short neuropeptide F (sNPF). Sleep induction by sNPF meets all relevant criteria. Rebound sleep following sleep deprivation is reduced by activation of sNPF neurons, and flies experience negative sleep rebound upon cessation of sNPF neuronal stimulation, indicating that sNPF provides an important signal to the sleep homeostat. Only a subset of sNPF-expressing neurons, which includes the small ventrolateral clock neurons, is sleep promoting. Their release of sNPF increases sleep consolidation in part by suppressing the activity of wake-promoting large ventrolateral clock neurons, and suppression of neuronal firing may be the general response to sNPF receptor activation. sNPF acutely increases sleep without altering feeding behavior, which it affects only on a much longer time scale. The profound effect of sNPF on sleep indicates that it is an important sleep-promoting molecule.
Volume 80(1)
Pages 171-83
Published 2013-10-2
DOI 10.1016/j.neuron.2013.07.029
PII S0896-6273(13)00653-3
PMID 24094110
PMC PMC3792499
MeSH Animals Brain / metabolism Cells, Cultured Drosophila Proteins / metabolism Drosophila melanogaster / metabolism* Feeding Behavior / physiology Neurons / metabolism* Neuropeptide Y / metabolism Neuropeptides / metabolism* Sleep / physiology* Sleep Deprivation / metabolism
IF 14.319
Times Cited 35
WOS Category NEUROSCIENCES
Resource
Drosophila sNPFGAL4 flies (NP6301 DGRC#113901)