RRC ID 327
Author Koana T, Takashima Y, Okada MO, Ikehata M, Miyakoshi J, Sakai K.
Title A threshold exists in the dose-response relationship for somatic mutation frequency induced by X irradiation of Drosophila.
Journal Radiat Res
Abstract The dose-response relationship of ionizing radiation and its stochastic effects has been thought to be linear without any thresholds. The basic data for this model were obtained from mutational assays in the male germ cells of the fruit fly Drosophila melanogaster. However, it is more appropriate to examine carcinogenic activity in somatic cells than in germ cells. Here the dose-response relationship of X irradiation and somatic mutation was examined in Drosophila. A threshold at approximately 1 Gy was observed in DNA repair-proficient flies. In the repair-deficient siblings, the threshold was smaller and the inclination of the dose-response curve was much steeper. These results suggest that the dose-response relationship between X irradiation and somatic mutation has a threshold and that the DNA repair function contributes to its formation.
Volume 161(4)
Pages 391-6
Published 2004-4-1
DOI 10.1667/rr3152
PII RR3152
PMID 15038774
MeSH Animals Crosses, Genetic DNA / radiation effects* DNA Damage DNA Repair Dose-Response Relationship, Radiation Drosophila melanogaster Female Genotype Humans Loss of Heterozygosity Mutagenesis Mutagenicity Tests* Mutation* Radiation, Ionizing Wings, Animal / radiation effects X-Rays
IF 2.779
Times Cited 24