論文 - 詳細
| RRC ID | 32813 |
|---|---|
| 著者 | Saga Y, Iba M, Tanji J, Hoshi E. |
| タイトル | Development of multidimensional representations of task phases in the lateral prefrontal cortex. |
| ジャーナル | J Neurosci |
| Abstract |
The temporal structuring of multiple events is essential for the purposeful regulation of behavior. We investigated the role of the lateral prefrontal cortex (LPFC) in transforming external signals of multiple sensory modalities into information suitable for monitoring successive events across behavioral phases until an intended action is prompted and then initiated. We trained monkeys to receive a succession of 1 s visual, auditory, or tactile sensory signals separated by variable intervals and to then release a key as soon as the fourth signal appeared. Thus, the animals had to monitor and update information about the progress of the task upon receiving each signal preceding the key release in response to the fourth signal. We found that the initial, short-latency responses of LPFC neurons reflected primarily the sensory modality, rather than the phase or progress of the task. However, a task phase-selective response developed within 500 ms of signal reception, and information about the task phase was maintained throughout the presentation of successive cues. The task phase-selective activity was updated with the appearance of each cue until the planned action was initiated. The phase-selective activity of individual neurons reflected not merely a particular phase of the task but also multiple successive phases. Furthermore, we found combined representations of task phase and sensory modality in the activity of individual LPFC neurons. These properties suggest how information representing multiple phases of behavioral events develops in the LPFC to provide a basis for the temporal regulation of behavior. |
| 巻・号 | 31(29) |
| ページ | 10648-65 |
| 公開日 | 2011-7-20 |
| DOI | 10.1523/JNEUROSCI.0988-11.2011 |
| PII | 31/29/10648 |
| PMID | 21775608 |
| PMC | PMC6622624 |
| MeSH | Acoustic Stimulation Action Potentials / physiology Analysis of Variance Animals Behavior, Animal Brain Mapping* Cues Female Macaca fascicularis Male Mental Recall / physiology* Neurons / physiology Photic Stimulation Prefrontal Cortex / cytology Prefrontal Cortex / physiology* Psychomotor Performance / physiology Reaction Time / physiology* Time Factors Touch |
| IF | 5.674 |
| 引用数 | 15 |
| WOS 分野 | NEUROSCIENCES |
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| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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