RRC ID 33030
著者 Loncle N, Agromayor M, Martin-Serrano J, Williams DW.
タイトル An ESCRT module is required for neuron pruning.
ジャーナル Sci Rep
Abstract Neural circuits are refined by both functional and structural changes. Structural remodeling by large-scale pruning occurs where relatively long neuronal branches are cut away from their parent neuron and removed by local degeneration. Until now, the molecular mechanisms executing such branch severing events have remained poorly understood. Here, we reveal a role for the Endosomal Sorting Complex Required for Transport (ESCRT) machinery during neuronal remodeling. Our data show that a specific ESCRT pruning module, including members of the ESCRT-I and ESCRT-III complexes, but not ESCRT-0 or ESCRT-II, are required for the neurite scission event during pruning. Furthermore we show that this ESCRT module requires a direct, in vivo, interaction between Shrub/CHMP4B and the accessory protein Myopic/HD-PTP.
巻・号 5
ページ 8461
公開日 2015-2-13
DOI 10.1038/srep08461
PII srep08461
PMID 25676218
PMC PMC4327575
MeSH Animals Dendrites / metabolism Drosophila / growth & development Drosophila / metabolism Drosophila Proteins / antagonists & inhibitors Drosophila Proteins / genetics Drosophila Proteins / metabolism Endosomal Sorting Complexes Required for Transport / antagonists & inhibitors Endosomal Sorting Complexes Required for Transport / genetics Endosomal Sorting Complexes Required for Transport / metabolism* Nerve Tissue Proteins / antagonists & inhibitors Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism Neurons / metabolism* Protein Tyrosine Phosphatases / antagonists & inhibitors Protein Tyrosine Phosphatases / genetics Protein Tyrosine Phosphatases / metabolism Pupa / metabolism RNA Interference RNA, Double-Stranded / metabolism
IF 3.998
引用数 39
WOS 分野 CELL BIOLOGY
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