論文 - 詳細
| RRC ID | 33035 |
|---|---|
| 著者 | Saez I, Duran J, Sinadinos C, Beltran A, Yanes O, Tevy MF, Martínez-Pons C, Milán M, Guinovart JJ. |
| タイトル | Neurons have an active glycogen metabolism that contributes to tolerance to hypoxia. |
| ジャーナル | J Cereb Blood Flow Metab |
| Abstract |
Glycogen is present in the brain, where it has been found mainly in glial cells but not in neurons. Therefore, all physiologic roles of brain glycogen have been attributed exclusively to astrocytic glycogen. Working with primary cultured neurons, as well as with genetically modified mice and flies, here we report that-against general belief-neurons contain a low but measurable amount of glycogen. Moreover, we also show that these cells express the brain isoform of glycogen phosphorylase, allowing glycogen to be fully metabolized. Most importantly, we show an active neuronal glycogen metabolism that protects cultured neurons from hypoxia-induced death and flies from hypoxia-induced stupor. Our findings change the current view of the role of glycogen in the brain and reveal that endogenous neuronal glycogen metabolism participates in the neuronal tolerance to hypoxic stress. |
| 巻・号 | 34(6) |
| ページ | 945-55 |
| 公開日 | 2014-6-1 |
| DOI | 10.1038/jcbfm.2014.33 |
| PII | jcbfm201433 |
| PMID | 24569689 |
| PMC | PMC4050236 |
| MeSH | Animals Cell Hypoxia / genetics Cells, Cultured Gene Expression Regulation, Enzymologic / genetics Glycogen / genetics Glycogen / metabolism* Glycogen Phosphorylase, Brain Form / biosynthesis Glycogen Phosphorylase, Brain Form / genetics Mice Mice, Transgenic Nerve Tissue Proteins / biosynthesis Nerve Tissue Proteins / genetics Neurons / cytology Neurons / metabolism* |
| IF | 5.681 |
| 引用数 | 87 |
| WOS 分野 | NEUROSCIENCES ENDOCRINOLOGY & METABOLISM HEMATOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 6904R-3 |