| RRC ID |
33035
|
| Author |
Saez I, Duran J, Sinadinos C, Beltran A, Yanes O, Tevy MF, Martínez-Pons C, Milán M, Guinovart JJ.
|
| Title |
Neurons have an active glycogen metabolism that contributes to tolerance to hypoxia.
|
| Journal |
J Cereb Blood Flow Metab
|
| Abstract |
Glycogen is present in the brain, where it has been found mainly in glial cells but not in neurons. Therefore, all physiologic roles of brain glycogen have been attributed exclusively to astrocytic glycogen. Working with primary cultured neurons, as well as with genetically modified mice and flies, here we report that-against general belief-neurons contain a low but measurable amount of glycogen. Moreover, we also show that these cells express the brain isoform of glycogen phosphorylase, allowing glycogen to be fully metabolized. Most importantly, we show an active neuronal glycogen metabolism that protects cultured neurons from hypoxia-induced death and flies from hypoxia-induced stupor. Our findings change the current view of the role of glycogen in the brain and reveal that endogenous neuronal glycogen metabolism participates in the neuronal tolerance to hypoxic stress.
|
| Volume |
34(6)
|
| Pages |
945-55
|
| Published |
2014-6-1
|
| DOI |
10.1038/jcbfm.2014.33
|
| PII |
jcbfm201433
|
| PMID |
24569689
|
| PMC |
PMC4050236
|
| MeSH |
Animals
Cell Hypoxia / genetics
Cells, Cultured
Gene Expression Regulation, Enzymologic / genetics
Glycogen / genetics
Glycogen / metabolism*
Glycogen Phosphorylase, Brain Form / biosynthesis
Glycogen Phosphorylase, Brain Form / genetics
Mice
Mice, Transgenic
Nerve Tissue Proteins / biosynthesis
Nerve Tissue Proteins / genetics
Neurons / cytology
Neurons / metabolism*
|
| IF |
5.681
|
| Times Cited |
87
|
|
WOS Category
|
NEUROSCIENCES
ENDOCRINOLOGY & METABOLISM
HEMATOLOGY
|
| Resource |
| Drosophila |
6904R-3 |
