RRC ID 33035
著者 Saez I, Duran J, Sinadinos C, Beltran A, Yanes O, Tevy MF, Martínez-Pons C, Milán M, Guinovart JJ.
タイトル Neurons have an active glycogen metabolism that contributes to tolerance to hypoxia.
ジャーナル J Cereb Blood Flow Metab
Abstract Glycogen is present in the brain, where it has been found mainly in glial cells but not in neurons. Therefore, all physiologic roles of brain glycogen have been attributed exclusively to astrocytic glycogen. Working with primary cultured neurons, as well as with genetically modified mice and flies, here we report that-against general belief-neurons contain a low but measurable amount of glycogen. Moreover, we also show that these cells express the brain isoform of glycogen phosphorylase, allowing glycogen to be fully metabolized. Most importantly, we show an active neuronal glycogen metabolism that protects cultured neurons from hypoxia-induced death and flies from hypoxia-induced stupor. Our findings change the current view of the role of glycogen in the brain and reveal that endogenous neuronal glycogen metabolism participates in the neuronal tolerance to hypoxic stress.
巻・号 34(6)
ページ 945-55
公開日 2014-6-1
DOI 10.1038/jcbfm.2014.33
PII jcbfm201433
PMID 24569689
PMC PMC4050236
MeSH Animals Cell Hypoxia / genetics Cells, Cultured Gene Expression Regulation, Enzymologic / genetics Glycogen / genetics Glycogen / metabolism* Glycogen Phosphorylase, Brain Form / biosynthesis Glycogen Phosphorylase, Brain Form / genetics Mice Mice, Transgenic Nerve Tissue Proteins / biosynthesis Nerve Tissue Proteins / genetics Neurons / cytology Neurons / metabolism*
IF 5.681
引用数 87
WOS 分野 NEUROSCIENCES ENDOCRINOLOGY & METABOLISM HEMATOLOGY
リソース情報
ショウジョウバエ 6904R-3