論文 - 詳細
| RRC ID | 33139 |
|---|---|
| 著者 | Sugahara R, Mon H, Lee JM, Shiotsuki T, Kusakabe T. |
| タイトル | Differential contribution of the Fanconi anemia-related proteins to repair of several types of DNA damage in cultured silkworm cells. |
| ジャーナル | FEBS Lett |
| Abstract |
The silkworm Fanconi anemia (FA) pathway is required for normal cellular resistance to mitomycin C (MMC) in silkworms, but little is known about the requirement for repair of other types of DNA damage. Here we report that silkworm cells deficient for FA proteins FancD2 and FancM exhibit normal sensitivities to hydroxyurea (HU) and camptothecin (CPT), although FancM-dependent FancD2 monoubiquitination is induced upon these treatments. Similar results were observed in cells depleted for Rmi1 and Mhf1, which interact with the FancM protein. We also found that Rad51-knockdown cells exhibited normal sensitivity to HU despite induction of double-strand breaks by HU treatment. |
| 巻・号 | 588(21) |
| ページ | 3959-63 |
| 公開日 | 2014-11-3 |
| DOI | 10.1016/j.febslet.2014.09.009 |
| PII | S0014-5793(14)00684-X |
| PMID | 25240201 |
| MeSH | Animals Bombyx / cytology* Camptothecin / pharmacology Cells, Cultured DNA Damage* DNA Helicases / deficiency DNA Helicases / metabolism* DNA Repair* Fanconi Anemia Complementation Group D2 Protein / deficiency Fanconi Anemia Complementation Group D2 Protein / metabolism* Histones / metabolism Homologous Recombination / drug effects Humans Hydroxyurea / pharmacology Mitomycin / pharmacology Phosphorylation / drug effects Ubiquitination / drug effects |
| IF | 3.057 |
| 引用数 | 1 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| カイコ | |