RRC ID 33363
Author Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA.
Title sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.
Journal Cell
Abstract Antagonists of several growth factor signaling pathways play important roles in developmental patterning by limiting the range of the cognate inducer. Here, we describe an antagonist of FGF signaling that patterns apical branching of the Drosophila airways. In wild-type embryos, the Branchless FGF induces secondary branching by activating the Breathless FGF receptor near the tips of growing primary branches. In sprouty mutants, the FGF pathway is overactive and ectopic branches are induced on the stalks of primary branches. We show that FGF signaling induces sprouty expression in the nearby tip cells, and sprouty acts nonautonomously and in a competitive fashion to block signaling to the more distant stalk cells. sprouty encodes a novel cysteine-rich protein that defines a new family of putative signaling molecules that may similarly function as FGF antagonists in vertebrate development.
Volume 92(2)
Pages 253-63
Published 1998-1-23
PII S0092-8674(00)80919-8
PMID 9458049
MeSH Amino Acid Sequence Animals Base Sequence Body Patterning / genetics* Cell Membrane / chemistry DNA, Complementary / genetics Drosophila / embryology* Drosophila / genetics Drosophila Proteins* Fibroblast Growth Factors / physiology* Gene Expression Regulation, Developmental Insect Proteins / analysis Insect Proteins / chemistry Insect Proteins / genetics* Membrane Proteins* Molecular Sequence Data Mutation Phenotype Restriction Mapping Sequence Analysis, DNA Signal Transduction / physiology* Trachea / embryology
IF 31.398
Times Cited 543
WOS Category BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
Resource
Drosophila