論文 - 詳細
| RRC ID | 33682 |
|---|---|
| 著者 | Reimer MM, Norris A, Ohnmacht J, Patani R, Zhong Z, Dias TB, Kuscha V, Scott AL, Chen YC, Rozov S, Frazer SL, Wyatt C, Higashijima S, Patton EE, Panula P, Chandran S, Becker T, Becker CG. |
| タイトル | Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration. |
| ジャーナル | Dev Cell |
| Abstract |
Coordinated development of brain stem and spinal target neurons is pivotal for the emergence of a precisely functioning locomotor system. Signals that match the development of these far-apart regions of the central nervous system may be redeployed during spinal cord regeneration. Here we show that descending dopaminergic projections from the brain promote motor neuron generation at the expense of V2 interneurons in the developing zebrafish spinal cord by activating the D4a receptor, which acts on the hedgehog pathway. Inhibiting this essential signal during early neurogenesis leads to a long-lasting reduction of motor neuron numbers and impaired motor responses of free-swimming larvae. Importantly, during successful spinal cord regeneration in adult zebrafish, endogenous dopamine promotes generation of spinal motor neurons, and dopamine agonists augment this process. Hence, we describe a supraspinal control mechanism for the development and regeneration of specific spinal cell types that uses dopamine as a signal. |
| 巻・号 | 25(5) |
| ページ | 478-91 |
| 公開日 | 2013-6-10 |
| DOI | 10.1016/j.devcel.2013.04.012 |
| PII | S1534-5807(13)00241-4 |
| PMID | 23707737 |
| MeSH | Animals Brain / embryology* Brain / metabolism* Dopamine / metabolism* Gene Expression Regulation, Developmental* Hedgehog Proteins / metabolism Immunohistochemistry Interneurons / metabolism Microscopy, Fluorescence Motor Neurons / cytology* Mutation Regeneration* Signal Transduction Spinal Cord / cytology Stem Cells / cytology Time Factors Zebrafish / embryology Zebrafish / growth & development |
| IF | 10.092 |
| 引用数 | 59 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(isl1:GFP)/rw0 |