Reference - Detail
|Author||Wang X, Kweon J, Larson S, Chen L.|
|Title||A role for the C. elegans L1CAM homologue lad-1/sax-7 in maintaining tissue attachment.|
The L1 family of cell adhesion molecules (L1CAMs) is important for neural development. Mutations in one of the human L1CAM genes, L1, can result in several neurological syndromes, the symptoms of which are variably penetrant. The physiological cause of these symptoms, collectively termed CRASH, is not clear. Caenorhabditis elegans animals genetically null for the L1CAM homologue LAD-1, exhibit variably penetrant pleiotropic phenotypes that are similar to the CRASH symptoms; thus the C. elegans lad-1 mutant provides an excellent model system to study how disruption of L1 leads to these abnormalities. These phenotypes include uncoordinated movements, variable embryonic lethality, and abnormal neuronal distribution and axon trajectories. Our analysis revealed that many of these phenotypes are likely a result of tissue detachment.
|MeSH||Animals Animals, Genetically Modified Axons Caenorhabditis elegans / cytology Caenorhabditis elegans / embryology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Adhesion* Cell Adhesion Molecules, Neuronal / genetics Cell Adhesion Molecules, Neuronal / metabolism* Chromosome Mapping Genes, Helminth Genes, Reporter Genetic Complementation Test Green Fluorescent Proteins / metabolism Helminth Proteins / genetics Helminth Proteins / metabolism* Microscopy, Video Models, Biological Morphogenesis Muscles / embryology Muscles / metabolism Mutation Neural Cell Adhesion Molecule L1 / genetics Neural Cell Adhesion Molecule L1 / metabolism* Neural Cell Adhesion Molecules / genetics Neural Cell Adhesion Molecules / metabolism* Neurons / cytology Neurons / metabolism Protein Isoforms / genetics Protein Isoforms / metabolism|
|WOS Category||DEVELOPMENTAL BIOLOGY|