論文 - 詳細
| RRC ID | 3425 |
|---|---|
| 著者 | Fukushige T, Brodigan TM, Schriefer LA, Waterston RH, Krause M. |
| タイトル | Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development. |
| ジャーナル | Genes Dev |
| Abstract |
Myogenic regulatory factors (MRFs) are required for mammalian skeletal myogenesis. In contrast, bodywall muscle is readily detectable in Caenorhabditis elegans embryos lacking activity of the lone MRF ortholog HLH-1, indicating that additional myogenic factors must function in the nematode. We find that two additional C. elegans proteins, UNC-120/SRF and HND-1/HAND, can convert naïve blastomeres to muscle when overproduced ectopically in the embryo. In addition, we have used genetic null mutants to demonstrate that both of these factors act in concert with HLH-1 to regulate myogenesis. Loss of all three factors results in embryos that lack detectable bodywall muscle differentiation, identifying this trio as a set that is both necessary and sufficient for bodywall myogenesis in C. elegans. In mammals, SRF and HAND play prominent roles in regulating smooth and cardiac muscle development. That C. elegans bodywall muscle development is dependent on transcription factors that are associated with all three types of mammalian muscle supports a theory that all animal muscle types are derived from a common ancestral contractile cell type. |
| 巻・号 | 20(24) |
| ページ | 3395-406 |
| 公開日 | 2006-12-15 |
| DOI | 10.1101/gad.1481706 |
| PII | gad.1481706 |
| PMID | 17142668 |
| PMC | PMC1698447 |
| MeSH | Animals Basic Helix-Loop-Helix Transcription Factors / genetics Basic Helix-Loop-Helix Transcription Factors / metabolism Biological Evolution Blastomeres / cytology Blastomeres / metabolism Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Cell Differentiation Gene Expression Regulation, Developmental* MADS Domain Proteins / genetics MADS Domain Proteins / metabolism Muscle Cells / cytology* Muscle Development / genetics* Muscle Proteins Mutation Myogenic Regulatory Factors / genetics Myogenic Regulatory Factors / metabolism Nuclear Proteins Transcription Factors |
| IF | 9.527 |
| 引用数 | 78 |
| WOS 分野 | GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| 線虫 | tm2090 tm1973 |