論文 - 詳細
| RRC ID | 3429 |
|---|---|
| 著者 | Hayes GD, Frand AR, Ruvkun G. |
| タイトル | The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. |
| ジャーナル | Development |
| Abstract |
The let-7 microRNA (miRNA) gene of Caenorhabditis elegans controls the timing of developmental events. let-7 is conserved throughout bilaterian phylogeny and has multiple paralogs. Here, we show that the paralog mir-84 acts synergistically with let-7 to promote terminal differentiation of the hypodermis and the cessation of molting in C. elegans. Loss of mir-84 exacerbates phenotypes caused by mutations in let-7, whereas increased expression of mir-84 suppresses a let-7 null allele. Adults with reduced levels of mir-84 and let-7 express genes characteristic of larval molting as they initiate a supernumerary molt. mir-84 and let-7 promote exit from the molting cycle by regulating targets in the heterochronic pathway and also nhr-23 and nhr-25, genes encoding conserved nuclear hormone receptors essential for larval molting. The synergistic action of miRNA paralogs in development may be a general feature of the diversified miRNA gene family. |
| 巻・号 | 133(23) |
| ページ | 4631-41 |
| 公開日 | 2006-12-1 |
| DOI | 10.1242/dev.02655 |
| PII | dev.02655 |
| PMID | 17065234 |
| MeSH | 3' Untranslated Regions Animals Base Sequence Binding Sites / genetics Caenorhabditis elegans / genetics* Caenorhabditis elegans / growth & development* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Conserved Sequence DNA Primers / genetics DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Gene Expression Regulation, Developmental Genes, Helminth MicroRNAs / genetics* Models, Genetic Molting / genetics Molting / physiology Mutation RNA, Helminth / genetics* Receptors, Cytoplasmic and Nuclear / genetics Receptors, Cytoplasmic and Nuclear / metabolism* Sequence Homology, Nucleic Acid Transcription Factors / genetics Transcription Factors / metabolism* |
| IF | 5.611 |
| 引用数 | 75 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1304 |