論文 - 詳細
| RRC ID | 34811 |
|---|---|
| 著者 | Hoffman CS, Wood V, Fantes PA. |
| タイトル | An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System. |
| ジャーナル | Genetics |
| Abstract |
The fission yeast Schizosaccharomyces pombe is an important model organism for the study of eukaryotic molecular and cellular biology. Studies of S. pombe, together with studies of its distant cousin, Saccharomyces cerevisiae, have led to the discovery of genes involved in fundamental mechanisms of transcription, translation, DNA replication, cell cycle control, and signal transduction, to name but a few processes. However, since the divergence of the two species approximately 350 million years ago, S. pombe appears to have evolved less rapidly than S. cerevisiae so that it retains more characteristics of the common ancient yeast ancestor, causing it to share more features with metazoan cells. This Primer introduces S. pombe by describing the yeast itself, providing a brief description of the origins of fission yeast research, and illustrating some genetic and bioinformatics tools used to study protein function in fission yeast. In addition, a section on some key differences between S. pombe and S. cerevisiae is included for readers with some familiarity with budding yeast research but who may have an interest in developing research projects using S. pombe. |
| 巻・号 | 201(2) |
| ページ | 403-23 |
| 公開日 | 2015-10-1 |
| DOI | 10.1534/genetics.115.181503 |
| PII | 201/2/403 |
| PMID | 26447128 |
| PMC | PMC4596657 |
| MeSH | Chromosomes, Fungal / genetics* DNA Damage / genetics DNA Replication / genetics* Genome, Fungal Homologous Recombination / genetics* Life Cycle Stages / genetics Models, Genetic Research Schizosaccharomyces / genetics* |
| IF | 4.015 |
| 引用数 | 75 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 61 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
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