RRC ID 34923
著者 Ishiguro K, Kim J, Fujiyama-Nakamura S, Kato S, Watanabe Y.
タイトル A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing.
ジャーナル EMBO Rep
Abstract We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21. Remarkably, RAD21L and REC8 have symmetrical, mutually exclusive localization on the not-yet-synapsed homologues, implying that the cohesin patterning could provide a code for homologue recognition. RAD21 transiently localizes to axial elements after the dissociation of RAD21L and REC8 in late pachytene, a period of recombination repair. Further, we show that the removal of cohesins and synaptonemal complex during late meiotic prophase is promoted by Polo-like kinase 1, which is similar to the mitotic prophase pathway.
巻・号 12(3)
ページ 267-75
公開日 2011-3-1
DOI 10.1038/embor.2011.2
PII embor20112
PMID 21274006
PMC PMC3059921
MeSH Amino Acid Sequence Animals Cell Cycle Proteins / chemistry Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism* Centromere Chromatography, Liquid Chromosomal Proteins, Non-Histone / chemistry Chromosomal Proteins, Non-Histone / genetics Chromosomal Proteins, Non-Histone / metabolism* Chromosome Pairing* Chromosome Segregation Chromosomes, Mammalian / metabolism* DNA-Binding Proteins Mass Spectrometry Meiosis* Mice Molecular Sequence Data Nuclear Proteins / metabolism Phosphoproteins / metabolism Prophase Protein Serine-Threonine Kinases / metabolism Protein Subunits Proto-Oncogene Proteins / metabolism Synaptonemal Complex / metabolism
IF 7.497
引用数 112
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
遺伝子材料 pCRII-mRAD21L (RDB12167)