| RRC ID |
35186
|
| 著者 |
Tenorio E, Saeki T, Fujita K, Kitakawa M, Baba T, Mori H, Isono K.
|
| タイトル |
Systematic characterization of Escherichia coli genes/ORFs affecting biofilm formation.
|
| ジャーナル |
FEMS Microbiol Lett
|
| Abstract |
To understand the nature and function of bacterial biofilm and the process of its formation, we have performed systematic screening of a complete set of Escherichia coli genes/open reading frames (ORFs) to identify those that affect biofilm development upon over-expression. In contrast to the biofilm of strain AG1 used as a control, some of the genes/ORFs when over-expressed led to the formation of an abnormal biofilm such as thin, mat-like, filamentous or one easily detaching from various surfaces. Disruptants of selected genes were constructed in order to clarify their roles in the different stages of biofilm formation. Our results suggest that diverse metabolic pathways contribute to the development of biofilm.
|
| 巻・号 |
225(1)
|
| ページ |
107-14
|
| 公開日 |
2003-8-8
|
| DOI |
10.1016/S0378-1097(03)00507-X
|
| PII |
S037810970300507X
|
| PMID |
12900028
|
| MeSH |
Bacterial Outer Membrane Proteins / genetics
Biofilms / growth & development*
Escherichia coli / genetics*
Escherichia coli / physiology*
Fimbriae, Bacterial / genetics
Gene Expression
Genes, Bacterial*
Mutagenesis
Open Reading Frames
Phenotype
|
| IF |
1.987
|
| 引用数 |
28
|
|
WOS 分野
|
MICROBIOLOGY
|
| リソース情報 |
| 原核生物(大腸菌) |
ME5305(AG1)? |
