RRC ID 3528
Author Ortiz CO, Etchberger JF, Posy SL, Frøkjaer-Jensen C, Lockery S, Honig B, Hobert O.
Title Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases.
Journal Genetics
Abstract 41% (11/27) of all receptor-type guanylyl cyclases are expressed in the ASE gustatory neurons and that one-third of all gcy genes (9/27) are expressed in a lateral, left/right asymmetric manner in the ASE neurons. The expression of all laterally expressed gcy genes is under the control of a gene regulatory network composed of several transcription factors and miRNAs. The complement of gcy genes in the related nematode C. briggsae differs from C. elegans as evidenced by differences in chromosomal localization, number of gcy genes, and expression patterns. Differences in gcy expression patterns in the ASE neurons of C. briggsae arise from a difference in cis-regulatory elements and trans-acting factors that control ASE laterality. In sum, our results indicate the existence of a surprising multitude of putative chemoreceptors in the gustatory ASE neurons and suggest the existence of a substantial degree of laterality in gustatory signaling mechanisms in nematodes.
Volume 173(1)
Pages 131-49
Published 2006-5
DOI 10.1534/genetics.106.055749
PII genetics.106.055749
PMID 16547101
PMC PMC1461427
MeSH Alleles Animals Body Patterning / genetics* Caenorhabditis elegans / cytology Caenorhabditis elegans / enzymology* Caenorhabditis elegans / genetics* Chromosomes / genetics Evolution, Molecular Gene Expression Profiling Gene Expression Regulation Genes, Helminth / genetics Genes, Reporter Genome, Helminth / genetics* Genomics Mutation / genetics Neurons / metabolism* Phylogeny Receptors, Guanylate Cyclase-Coupled / chemistry Receptors, Guanylate Cyclase-Coupled / genetics* Sequence Homology, Nucleic Acid Species Specificity Synteny / genetics
IF 4.075
Times Cited 61
C.elegans tm897