| RRC ID |
3528
|
| Author |
Ortiz CO, Etchberger JF, Posy SL, Frøkjaer-Jensen C, Lockery S, Honig B, Hobert O.
|
| Title |
Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases.
|
| Journal |
Genetics
|
| Abstract |
41% (11/27) of all receptor-type guanylyl cyclases are expressed in the ASE gustatory neurons and that one-third of all gcy genes (9/27) are expressed in a lateral, left/right asymmetric manner in the ASE neurons. The expression of all laterally expressed gcy genes is under the control of a gene regulatory network composed of several transcription factors and miRNAs. The complement of gcy genes in the related nematode C. briggsae differs from C. elegans as evidenced by differences in chromosomal localization, number of gcy genes, and expression patterns. Differences in gcy expression patterns in the ASE neurons of C. briggsae arise from a difference in cis-regulatory elements and trans-acting factors that control ASE laterality. In sum, our results indicate the existence of a surprising multitude of putative chemoreceptors in the gustatory ASE neurons and suggest the existence of a substantial degree of laterality in gustatory signaling mechanisms in nematodes.
|
| Volume |
173(1)
|
| Pages |
131-49
|
| Published |
2006-5
|
| DOI |
10.1534/genetics.106.055749
|
| PII |
genetics.106.055749
|
| PMID |
16547101
|
| PMC |
PMC1461427
|
| MeSH |
Alleles
Animals
Body Patterning / genetics*
Caenorhabditis elegans / cytology
Caenorhabditis elegans / enzymology*
Caenorhabditis elegans / genetics*
Chromosomes / genetics
Evolution, Molecular
Gene Expression Profiling
Gene Expression Regulation
Genes, Helminth / genetics
Genes, Reporter
Genome, Helminth / genetics*
Genomics
Mutation / genetics
Neurons / metabolism*
Phylogeny
Receptors, Guanylate Cyclase-Coupled / chemistry
Receptors, Guanylate Cyclase-Coupled / genetics*
Sequence Homology, Nucleic Acid
Species Specificity
Synteny / genetics
|
| IF |
4.075
|
| Times Cited |
61
|
|
WOS Category
|
GENETICS & HEREDITY
|
| Resource |
| C.elegans |
tm897 |
