論文 - 詳細
| RRC ID | 35534 |
|---|---|
| 著者 | Brito PH, Rocha EP, Xavier KB, Gordo I. |
| タイトル | Natural genome diversity of AI-2 quorum sensing in Escherichia coli: conserved signal production but labile signal reception. |
| ジャーナル | Genome Biol Evol |
| Abstract |
Quorum sensing (QS) regulates the onset of bacterial social responses in function to cell density having an important impact in virulence. Autoinducer-2 (AI-2) is a signal that has the peculiarity of mediating both intra- and interspecies bacterial QS. We analyzed the diversity of all components of AI-2 QS across 44 complete genomes of Escherichia coli and Shigella strains. We used phylogenetic tools to study its evolution and determined the phenotypes of single-deletion mutants to predict phenotypes of natural strains. Our analysis revealed many likely adaptive polymorphisms both in gene content and in nucleotide sequence. We show that all natural strains possess the signal emitter (the luxS gene), but many lack a functional signal receptor (complete lsr operon) and the ability to regulate extracellular signal concentrations. This result is in striking contrast with the canonical species-specific QS systems where one often finds orphan receptors, without a cognate synthase, but not orphan emitters. Our analysis indicates that selection actively maintains a balanced polymorphism for the presence/absence of a functional lsr operon suggesting diversifying selection on the regulation of signal accumulation and recognition. These results can be explained either by niche-specific adaptation or by selection for a coercive behavior where signal-blind emitters benefit from forcing other individuals in the population to haste in cooperative behaviors. |
| 巻・号 | 5(1) |
| ページ | 16-30 |
| 公開日 | 2013-1-1 |
| DOI | 10.1093/gbe/evs122 |
| PII | evs122 |
| PMID | 23246794 |
| PMC | PMC3595036 |
| MeSH | Adaptation, Physiological / genetics Bacterial Proteins / genetics Carbon-Sulfur Lyases / genetics Escherichia coli / genetics* Escherichia coli Proteins / genetics Evolution, Molecular Gene Deletion Genome, Bacterial* Mutation Operon Phenotype Phylogeny Polymorphism, Genetic* Quorum Sensing* Repressor Proteins / genetics Selection, Genetic Shigella / genetics Signal Transduction / genetics* |
| IF | 3.462 |
| 引用数 | 13 |
| WOS 分野 | GENETICS & HEREDITY EVOLUTIONARY BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 原核生物(大腸菌) | Keio collection |