RRC ID 3558
著者 Abraham MC, Lu Y, Shaham S.
タイトル A morphologically conserved nonapoptotic program promotes linker cell death in Caenorhabditis elegans.
ジャーナル Dev Cell
Abstract Apoptosis, cell death characterized by stereotypical morphological features, requires caspase proteases. Nonapoptotic, caspase-independent cell death pathways have been postulated; however, little is known about their molecular constituents or in vivo functions. Here, we show that death of the Caenorhabditis elegans linker cell during development is independent of the ced-3 caspase and all known cell death genes. The linker cell employs a cell-autonomous death program, and a previously undescribed engulfment program is required for its clearance. Dying linker cells display nonapoptotic features, including nuclear crenellation, absence of chromatin condensation, organelle swelling, and accumulation of cytoplasmic membrane-bound structures. Similar features are seen during developmental death of neurons in the vertebrate spinal cord and ciliary ganglia. Linker cell death is controlled by the microRNA let-7 and Zn-finger protein LIN-29, components of the C. elegans developmental timing pathway. We propose that the program executing linker cell death is conserved and used during vertebrate development.
巻・号 12(1)
ページ 73-86
公開日 2007-1-1
DOI 10.1016/j.devcel.2006.11.012
PII S1534-5807(06)00517-X
PMID 17199042
MeSH Animals Caenorhabditis elegans / cytology* Caenorhabditis elegans / ultrastructure Cell Death Genes, Developmental Male Mutation / genetics Phagocytosis / physiology Wallerian Degeneration
IF 10.092
引用数 76
WOS 分野 DEVELOPMENTAL BIOLOGY CELL BIOLOGY
リソース情報
線虫 tm917 tm1079