Reference - Detail
| RRC ID | 3558 |
|---|---|
| Author | Abraham MC, Lu Y, Shaham S. |
| Title | A morphologically conserved nonapoptotic program promotes linker cell death in Caenorhabditis elegans. |
| Journal | Dev Cell |
| Abstract |
Apoptosis, cell death characterized by stereotypical morphological features, requires caspase proteases. Nonapoptotic, caspase-independent cell death pathways have been postulated; however, little is known about their molecular constituents or in vivo functions. Here, we show that death of the Caenorhabditis elegans linker cell during development is independent of the ced-3 caspase and all known cell death genes. The linker cell employs a cell-autonomous death program, and a previously undescribed engulfment program is required for its clearance. Dying linker cells display nonapoptotic features, including nuclear crenellation, absence of chromatin condensation, organelle swelling, and accumulation of cytoplasmic membrane-bound structures. Similar features are seen during developmental death of neurons in the vertebrate spinal cord and ciliary ganglia. Linker cell death is controlled by the microRNA let-7 and Zn-finger protein LIN-29, components of the C. elegans developmental timing pathway. We propose that the program executing linker cell death is conserved and used during vertebrate development. |
| Volume | 12(1) |
| Pages | 73-86 |
| Published | 2007-1-1 |
| DOI | 10.1016/j.devcel.2006.11.012 |
| PII | S1534-5807(06)00517-X |
| PMID | 17199042 |
| MeSH | Animals Caenorhabditis elegans / cytology* Caenorhabditis elegans / ultrastructure Cell Death Genes, Developmental Male Mutation / genetics Phagocytosis / physiology Wallerian Degeneration |
| IF | 10.092 |
| Times Cited | 76 |
| WOS Category | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 7 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1079 tm917 |