論文 - 詳細
| RRC ID | 3558 |
|---|---|
| 著者 | Abraham MC, Lu Y, Shaham S. |
| タイトル | A morphologically conserved nonapoptotic program promotes linker cell death in Caenorhabditis elegans. |
| ジャーナル | Dev Cell |
| Abstract |
Apoptosis, cell death characterized by stereotypical morphological features, requires caspase proteases. Nonapoptotic, caspase-independent cell death pathways have been postulated; however, little is known about their molecular constituents or in vivo functions. Here, we show that death of the Caenorhabditis elegans linker cell during development is independent of the ced-3 caspase and all known cell death genes. The linker cell employs a cell-autonomous death program, and a previously undescribed engulfment program is required for its clearance. Dying linker cells display nonapoptotic features, including nuclear crenellation, absence of chromatin condensation, organelle swelling, and accumulation of cytoplasmic membrane-bound structures. Similar features are seen during developmental death of neurons in the vertebrate spinal cord and ciliary ganglia. Linker cell death is controlled by the microRNA let-7 and Zn-finger protein LIN-29, components of the C. elegans developmental timing pathway. We propose that the program executing linker cell death is conserved and used during vertebrate development. |
| 巻・号 | 12(1) |
| ページ | 73-86 |
| 公開日 | 2007-1-1 |
| DOI | 10.1016/j.devcel.2006.11.012 |
| PII | S1534-5807(06)00517-X |
| PMID | 17199042 |
| MeSH | Animals Caenorhabditis elegans / cytology* Caenorhabditis elegans / ultrastructure Cell Death Genes, Developmental Male Mutation / genetics Phagocytosis / physiology Wallerian Degeneration |
| IF | 10.092 |
| 引用数 | 76 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1079 tm917 |