論文 - 詳細
RRC ID | 3562 |
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著者 | Boerckel J, Walker D, Ahmed S. |
タイトル | The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replication. |
ジャーナル | Genetics |
Abstract |
Subunits of the Rad9/Rad1/Hus1 (9-1-1) proliferating cell nuclear antigen (PNCA)-like sliding clamp are required for DNA damage responses and telomerase-mediated telomere replication in the nematode Caenorhabditis elegans. PCNA sliding clamps are loaded onto DNA by a replication factor C (RFC) clamp loader. The C. elegans Rad17 RFC clamp loader homolog, hpr-17, functions in the same pathway as the 9-1-1 complex with regard to both the DNA damage response and telomerase-mediated telomere elongation. Thus, hpr-17 defines an RFC-like complex that facilitates telomerase activity in vivo in C. elegans. |
巻・号 | 176(1) |
ページ | 703-9 |
公開日 | 2007-5-1 |
DOI | 10.1534/genetics.106.070201 |
PII | genetics.106.070201 |
PMID | 17339221 |
PMC | PMC1893056 |
MeSH | Animals Apoptosis / radiation effects Caenorhabditis elegans / genetics* Caenorhabditis elegans / radiation effects Caenorhabditis elegans Proteins / metabolism* Cell Cycle / radiation effects Cell Cycle Proteins / metabolism* DNA Damage DNA Replication* / radiation effects Mutation / genetics Nuclear Proteins / metabolism* Radiation, Ionizing Repetitive Sequences, Nucleic Acid / genetics Sequence Homology, Amino Acid* Telomerase / metabolism Telomere / metabolism* |
IF | 4.015 |
引用数 | 14 |
WOS 分野 | GENETICS & HEREDITY |
リソース情報 | |
線虫 | tm1579 tm1279 |