RRC ID 3562
Author Boerckel J, Walker D, Ahmed S.
Title The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replication.
Journal Genetics
Abstract Subunits of the Rad9/Rad1/Hus1 (9-1-1) proliferating cell nuclear antigen (PNCA)-like sliding clamp are required for DNA damage responses and telomerase-mediated telomere replication in the nematode Caenorhabditis elegans. PCNA sliding clamps are loaded onto DNA by a replication factor C (RFC) clamp loader. The C. elegans Rad17 RFC clamp loader homolog, hpr-17, functions in the same pathway as the 9-1-1 complex with regard to both the DNA damage response and telomerase-mediated telomere elongation. Thus, hpr-17 defines an RFC-like complex that facilitates telomerase activity in vivo in C. elegans.
Volume 176(1)
Pages 703-9
Published 2007-5-1
DOI 10.1534/genetics.106.070201
PII genetics.106.070201
PMID 17339221
PMC PMC1893056
MeSH Animals Apoptosis / radiation effects Caenorhabditis elegans / genetics* Caenorhabditis elegans / radiation effects Caenorhabditis elegans Proteins / metabolism* Cell Cycle / radiation effects Cell Cycle Proteins / metabolism* DNA Damage DNA Replication* / radiation effects Mutation / genetics Nuclear Proteins / metabolism* Radiation, Ionizing Repetitive Sequences, Nucleic Acid / genetics Sequence Homology, Amino Acid* Telomerase / metabolism Telomere / metabolism*
IF 3.564
Times Cited 14
C.elegans tm1579 tm1279