RRC ID 3562
著者 Boerckel J, Walker D, Ahmed S.
タイトル The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replication.
ジャーナル Genetics
Abstract Subunits of the Rad9/Rad1/Hus1 (9-1-1) proliferating cell nuclear antigen (PNCA)-like sliding clamp are required for DNA damage responses and telomerase-mediated telomere replication in the nematode Caenorhabditis elegans. PCNA sliding clamps are loaded onto DNA by a replication factor C (RFC) clamp loader. The C. elegans Rad17 RFC clamp loader homolog, hpr-17, functions in the same pathway as the 9-1-1 complex with regard to both the DNA damage response and telomerase-mediated telomere elongation. Thus, hpr-17 defines an RFC-like complex that facilitates telomerase activity in vivo in C. elegans.
巻・号 176(1)
ページ 703-9
公開日 2007-5-1
DOI 10.1534/genetics.106.070201
PII genetics.106.070201
PMID 17339221
PMC PMC1893056
MeSH Animals Apoptosis / radiation effects Caenorhabditis elegans / genetics* Caenorhabditis elegans / radiation effects Caenorhabditis elegans Proteins / metabolism* Cell Cycle / radiation effects Cell Cycle Proteins / metabolism* DNA Damage DNA Replication* / radiation effects Mutation / genetics Nuclear Proteins / metabolism* Radiation, Ionizing Repetitive Sequences, Nucleic Acid / genetics Sequence Homology, Amino Acid* Telomerase / metabolism Telomere / metabolism*
IF 4.015
引用数 14
WOS 分野 GENETICS & HEREDITY
リソース情報
線虫 tm1579 tm1279