論文 - 詳細
| RRC ID | 35782 |
|---|---|
| 著者 | Tashiro S, Handa T, Matsuda A, Ban T, Takigawa T, Miyasato K, Ishii K, Kugou K, Ohta K, Hiraoka Y, Masukata H, Kanoh J. |
| タイトル | Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing. |
| ジャーナル | Nat Commun |
| Abstract |
A chromosome is composed of structurally and functionally distinct domains. However, the molecular mechanisms underlying the formation of chromatin structure and the function of subtelomeres, the telomere-adjacent regions, remain obscure. Here we report the roles of the conserved centromeric protein Shugoshin 2 (Sgo2) in defining chromatin structure and functions of the subtelomeres in the fission yeast Schizosaccharomyces pombe. We show that Sgo2 localizes at the subtelomeres preferentially during G2 phase and is essential for the formation of a highly condensed subtelomeric chromatin body 'knob'. Furthermore, the absence of Sgo2 leads to the derepression of the subtelomeric genes and premature DNA replication at the subtelomeric late origins. Thus, the subtelomeric specialized chromatin domain organized by Sgo2 represses both transcription and replication to ensure proper gene expression and replication timing. |
| 巻・号 | 7 |
| ページ | 10393 |
| 公開日 | 2016-1-25 |
| DOI | 10.1038/ncomms10393 |
| PII | ncomms10393 |
| PMID | 26804021 |
| PMC | PMC4737732 |
| MeSH | Chromatin / genetics Chromatin / metabolism* Chromosomal Proteins, Non-Histone / chemistry* Chromosomal Proteins, Non-Histone / genetics Chromosomal Proteins, Non-Histone / metabolism* DNA Replication Timing* G2 Phase Protein Structure, Tertiary Protein Transport Schizosaccharomyces / chemistry Schizosaccharomyces / cytology Schizosaccharomyces / genetics* Schizosaccharomyces / metabolism* Schizosaccharomyces pombe Proteins / chemistry* Schizosaccharomyces pombe Proteins / genetics Schizosaccharomyces pombe Proteins / metabolism* Telomere / genetics Telomere / metabolism* Transcription, Genetic |
| IF | 12.121 |
| 引用数 | 13 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | |