Reference - Detail
| RRC ID | 3581 |
|---|---|
| Author | Haynes CM, Petrova K, Benedetti C, Yang Y, Ron D. |
| Title | ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. |
| Journal | Dev Cell |
| Abstract |
The cellular response to unfolded and misfolded proteins in the mitochondrial matrix is poorly understood. Here, we report on a genome-wide RNAi-based screen for genes that signal the mitochondrial unfolded protein response (UPR(mt)) in C. elegans. Unfolded protein stress in the mitochondria correlates with complex formation between a homeodomain-containing transcription factor DVE-1 and the small ubiquitin-like protein UBL-5, both of which are encoded by genes required for signaling the UPR(mt). Activation of the UPR(mt) correlates temporally and spatially with nuclear redistribution of DVE-1 and with its enhanced binding to the promoters of mitochondrial chaperone genes. These events and the downstream UPR(mt) are attenuated in animals with reduced activity of clpp-1, which encodes a mitochondrial matrix protease homologous to bacterial ClpP. As ClpP is known to function in the bacterial heat-shock response, our findings suggest that eukaryotes utilize component(s) from the protomitochondrial symbiont to signal the UPR(mt). |
| Volume | 13(4) |
| Pages | 467-80 |
| Published | 2007-10-1 |
| DOI | 10.1016/j.devcel.2007.07.016 |
| PII | S1534-5807(07)00277-8 |
| PMID | 17925224 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / embryology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Nucleus / metabolism Embryo, Nonmammalian Endopeptidase Clp / genetics Endopeptidase Clp / metabolism* Escherichia coli Proteins / genetics Genome, Helminth Mitochondria / metabolism* Molecular Chaperones / genetics Molecular Chaperones / metabolism Mutation Promoter Regions, Genetic Protein Folding* Signal Transduction Transcription Factors / metabolism* Ubiquitins / genetics Ubiquitins / metabolism* |
| IF | 10.092 |
| Times Cited | 295 |
| WOS Category | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm259 |