論文 - 詳細
| RRC ID | 3615 |
|---|---|
| 著者 | Quevedo C, Kaplan DR, Derry WB. |
| タイトル | AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. |
| ジャーナル | Curr Biol |
| Abstract |
The cellular response to genotoxic stress involves the integration of multiple prosurvival and proapoptotic signals that dictate whether a cell lives or dies. In mammals, AKT/PKB regulates cell survival by modulating the activity of several apoptotic proteins, including p53. In Caenorhabditis elegans, akt-1 and akt-2 regulate development in response to environmental cues by controlling the FOXO transcription factor daf-16, but the role of these genes in regulating p53-dependent apoptosis is not known. In this study, we show that akt-1 and akt-2 negatively regulate DNA-damage-induced apoptosis in the C. elegans germline. The antiapoptotic activity of akt-1 is independent of its target gene daf-16 but dependent on cep-1/p53. Although only akt-1 regulates the apoptotic activity of cep-1, both akt-1 and akt-2 modulate the intensity of the apoptotic response independently of the transcriptional activity of CEP-1. Finally, we show that AKT-1 regulates apoptosis but not cell-cycle progression downstream of the HUS-1/MRT-2 branch of the DNA damage checkpoint. |
| 巻・号 | 17(3) |
| ページ | 286-92 |
| 公開日 | 2007-2-6 |
| DOI | 10.1016/j.cub.2006.12.038 |
| PII | S0960-9822(06)02672-8 |
| PMID | 17276923 |
| MeSH | Animals Apoptosis* Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* DNA Damage* / radiation effects Forkhead Transcription Factors Germ Cells / cytology* Mutation Proto-Oncogene Proteins c-akt / genetics Proto-Oncogene Proteins c-akt / metabolism* Radiation, Ionizing |
| IF | 9.601 |
| 引用数 | 44 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1075 |