論文 - 詳細
| RRC ID | 36199 |
|---|---|
| 著者 | Oda Y, Kimura M, Kose S, Fasken MB, Corbett AH, Imamoto N. |
| タイトル | The Schizosaccharomyces pombe Hikeshi/Opi10 protein has similar biochemical functions to its human homolog but acts in different physiological contexts. |
| ジャーナル | FEBS Lett |
| Abstract |
Human Hikeshi (HsHikeshi) is a nuclear import carrier for Hsp70s and is required for cell survival after heat shock. The Hikeshi homolog in Schizosaccharomyces pombe (SpHikeshi/Opi10) localizes to the nuclear rim, interacts with the Hsp70 homolog Ssa2, and mediates its nuclear import in a reconstituted mammalian nuclear transport system. However, SpHikeshi/Opi10 is not required for heat stress response and survival after heat stress. Instead, SpHikeshi/Opi10 is required for the normal expression of stress response genes under optimal conditions and for cell growth during glucose deprivation. Here, the functions of SpHikeshi/Opi10 are discussed and compared to the functions of HsHikeshi. |
| 巻・号 | 588(10) |
| ページ | 1899-905 |
| 公開日 | 2014-5-21 |
| DOI | 10.1016/j.febslet.2014.04.018 |
| PII | S0014-5793(14)00304-4 |
| PMID | 24768994 |
| MeSH | Active Transport, Cell Nucleus Amino Acid Sequence Carrier Proteins / genetics Carrier Proteins / metabolism* Cell Nucleus / metabolism Gene Expression Regulation, Fungal HSP70 Heat-Shock Proteins / genetics HSP70 Heat-Shock Proteins / metabolism HeLa Cells Heat-Shock Response* Humans Luminescent Proteins / genetics Luminescent Proteins / metabolism Microscopy, Fluorescence Molecular Sequence Data Mutation Oligonucleotide Array Sequence Analysis Protein Binding Schizosaccharomyces / genetics Schizosaccharomyces / growth & development Schizosaccharomyces / metabolism* Schizosaccharomyces pombe Proteins / genetics Schizosaccharomyces pombe Proteins / metabolism* Sequence Homology, Amino Acid Temperature Transcriptome |
| IF | 3.057 |
| 引用数 | 4 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | spa73g12 and spa101a06 |