| RRC ID |
36199
|
| 著者 |
Oda Y, Kimura M, Kose S, Fasken MB, Corbett AH, Imamoto N.
|
| タイトル |
The Schizosaccharomyces pombe Hikeshi/Opi10 protein has similar biochemical functions to its human homolog but acts in different physiological contexts.
|
| ジャーナル |
FEBS Lett
|
| Abstract |
Human Hikeshi (HsHikeshi) is a nuclear import carrier for Hsp70s and is required for cell survival after heat shock. The Hikeshi homolog in Schizosaccharomyces pombe (SpHikeshi/Opi10) localizes to the nuclear rim, interacts with the Hsp70 homolog Ssa2, and mediates its nuclear import in a reconstituted mammalian nuclear transport system. However, SpHikeshi/Opi10 is not required for heat stress response and survival after heat stress. Instead, SpHikeshi/Opi10 is required for the normal expression of stress response genes under optimal conditions and for cell growth during glucose deprivation. Here, the functions of SpHikeshi/Opi10 are discussed and compared to the functions of HsHikeshi.
|
| 巻・号 |
588(10)
|
| ページ |
1899-905
|
| 公開日 |
2014-5-21
|
| DOI |
10.1016/j.febslet.2014.04.018
|
| PII |
S0014-5793(14)00304-4
|
| PMID |
24768994
|
| MeSH |
Active Transport, Cell Nucleus
Amino Acid Sequence
Carrier Proteins / genetics
Carrier Proteins / metabolism*
Cell Nucleus / metabolism
Gene Expression Regulation, Fungal
HSP70 Heat-Shock Proteins / genetics
HSP70 Heat-Shock Proteins / metabolism
HeLa Cells
Heat-Shock Response*
Humans
Luminescent Proteins / genetics
Luminescent Proteins / metabolism
Microscopy, Fluorescence
Molecular Sequence Data
Mutation
Oligonucleotide Array Sequence Analysis
Protein Binding
Schizosaccharomyces / genetics
Schizosaccharomyces / growth & development
Schizosaccharomyces / metabolism*
Schizosaccharomyces pombe Proteins / genetics
Schizosaccharomyces pombe Proteins / metabolism*
Sequence Homology, Amino Acid
Temperature
Transcriptome
|
| IF |
3.057
|
| 引用数 |
4
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| 酵母 |
spa73g12 and spa101a06 |
