Reference - Detail
| RRC ID | 36235 |
|---|---|
| Author | Sun X, Yang H, Sturgill D, Oliver B, Rabinow L, Samson ML. |
| Title | Sxl-Dependent, tra/tra2-Independent Alternative Splicing of the Drosophila melanogaster X-Linked Gene found in neurons. |
| Journal | G3 (Bethesda) |
| Abstract |
Somatic sexual determination and behavior in Drosophila melanogaster are under the control of a genetic cascade initiated by Sex lethal (Sxl). In the female soma, SXL RNA-binding protein regulates the splicing of transformer (tra) transcripts into a female-specific form. The RNA-binding protein TRA and its cofactor TRA2 function in concert in females, whereas SXL, TRA, and TRA2 are thought to not function in males. To better understand sex-specific regulation of gene expression, we analyzed male and female head transcriptome datasets for expression levels and splicing, quantifying sex-biased gene expression via RNA-Seq and qPCR. Our data uncouple the effects of Sxl and tra/tra2 in females in the-sex-biased alternative splicing of head transcripts from the X-linked locus found in neurons (fne), encoding a pan-neuronal RNA-binding protein of the ELAV family. We show that FNE protein levels are downregulated by Sxl in female heads, also independently of tra/tra2. We argue that this regulation may have important sexually dimorphic consequences for the regulation of nervous system development or function. |
| Volume | 5(12) |
| Pages | 2865-74 |
| Published | 2015-10-28 |
| DOI | 10.1534/g3.115.023721 |
| PII | g3.115.023721 |
| PMID | 26511498 |
| PMC | PMC4683657 |
| MeSH | Alleles Alternative Splicing* Animals Drosophila Proteins / genetics* Drosophila Proteins / metabolism* Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism* Female Gene Expression Profiling Gene Expression Regulation Genes, X-Linked* High-Throughput Nucleotide Sequencing Male Mutation Neurons / metabolism* Nuclear Proteins / genetics* RNA-Binding Proteins / metabolism* Ribonucleoproteins / genetics* Transcriptome |
| IF | 2.781 |
| Times Cited | 6 |
| WOS Category | GENETICS & HEREDITY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#101894 DGRC#101842 |