論文 - 詳細
| RRC ID | 36246 |
|---|---|
| 著者 | Tanaka C, Tan LJ, Mochida K, Kirisako H, Koizumi M, Asai E, Sakoh-Nakatogawa M, Ohsumi Y, Nakatogawa H. |
| タイトル | Hrr25 triggers selective autophagy-related pathways by phosphorylating receptor proteins. |
| ジャーナル | J Cell Biol |
| Abstract |
In selective autophagy, degradation targets are specifically recognized, sequestered by the autophagosome, and transported into the lysosome or vacuole. Previous studies delineated the molecular basis by which the autophagy machinery recognizes those targets, but the regulation of this process is still poorly understood. In this paper, we find that the highly conserved multifunctional kinase Hrr25 regulates two distinct selective autophagy-related pathways in Saccharomyces cerevisiae. Hrr25 is responsible for the phosphorylation of two receptor proteins: Atg19, which recognizes the assembly of vacuolar enzymes in the cytoplasm-to-vacuole targeting pathway, and Atg36, which recognizes superfluous peroxisomes in pexophagy. Hrr25-mediated phosphorylation enhances the interactions of these receptors with the common adaptor Atg11, which recruits the core autophagy-related proteins that mediate the formation of the autophagosomal membrane. Thus, this study introduces regulation of selective autophagy as a new role of Hrr25 and, together with other recent studies, reveals that different selective autophagy-related pathways are regulated by a uniform mechanism: phosphoregulation of the receptor-adaptor interaction. |
| 巻・号 | 207(1) |
| ページ | 91-105 |
| 公開日 | 2014-10-13 |
| DOI | 10.1083/jcb.201402128 |
| PII | jcb.201402128 |
| PMID | 25287303 |
| PMC | PMC4195827 |
| MeSH | Aminopeptidases / metabolism Autophagy / physiology* Autophagy-Related Proteins Binding Sites / genetics COP-Coated Vesicles / metabolism Casein Kinase I / genetics Casein Kinase I / metabolism* GTPase-Activating Proteins / metabolism Membrane Proteins / metabolism Mitochondria / metabolism Mutation Peroxins Peroxisomes / metabolism Phosphorylation Promoter Regions, Genetic Protein Binding Protein Transport Receptors, Cell Surface / metabolism* Saccharomyces cerevisiae / metabolism* Saccharomyces cerevisiae Proteins / genetics Saccharomyces cerevisiae Proteins / metabolism* Vesicular Transport Proteins / metabolism* |
| IF | 8.811 |
| 引用数 | 66 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | AID system |