RRC ID 36253
Author Okamoto N, Nishimura T.
Title Signaling from Glia and Cholinergic Neurons Controls Nutrient-Dependent Production of an Insulin-like Peptide for Drosophila Body Growth.
Journal Dev Cell
Abstract The insulin-like peptide (ILP) family plays key biological roles in the control of body growth. Although the functions of ILPs are well understood, the mechanisms by which organisms sense their nutrient status and thereby control ILP production remain largely unknown. Here, we show that signaling relay and feedback mechanisms control the nutrient-dependent expression of Drosophila ILP5 (Dilp5). The expression of dilp5 in brain insulin-producing cells (IPCs) is negatively regulated by the transcription factor FoxO. Glia-derived Dilp6 remotely regulates the FoxO activity in IPCs, primarily through Jeb secreted by cholinergic neurons. Dilp6 production by surface glia is amplified by cellular response to circulating Dilps derived from IPCs, in concert with amino acid signals. The induction of dilp5 is critical for sustaining body growth under restricted food conditions. These results provide a molecular framework that explains how the production of an endocrine hormone in a specific tissue is coordinated with environmental conditions.
Volume 35(3)
Pages 295-310
Published 2015-11-9
DOI 10.1016/j.devcel.2015.10.003
PII S1534-5807(15)00650-4
PMID 26555050
MeSH Animals Brain / growth & development Brain / metabolism Cholinergic Neurons / metabolism* Drosophila Proteins / metabolism* Drosophila melanogaster / growth & development Drosophila melanogaster / metabolism* Gene Expression Regulation, Developmental / physiology Insulin / metabolism* Neuroglia / metabolism* Proteins / metabolism* Signal Transduction / genetics Signal Transduction / physiology
IF 10.092
Times Cited 33
Drosophila DGRC#103877 DGRC#112001 DGRC#113901 DGRC#106098 DGRC#112853 DGRC#112228 DGRC#113173 DGRC#105240