| RRC ID |
36297
|
| 著者 |
Sheik Mohideen S, Yamasaki Y, Omata Y, Tsuda L, Yoshiike Y.
|
| タイトル |
Nontoxic singlet oxygen generator as a therapeutic candidate for treating tauopathies.
|
| ジャーナル |
Sci Rep
|
| Abstract |
Methylene blue (MB) inhibits the aggregation of tau, a main constituent of neurofibrillary tangles. However, MB's mode of action in vivo is not fully understood. MB treatment reduced the amount of sarkosyl-insoluble tau in Drosophila that express human wild-type tau. MB concurrently ameliorated the climbing deficits of transgenic tau flies to a limited extent and diminished the climbing activity of wild-type flies. MB also decreased the survival rate of wild-type flies. Based on its photosensitive efficacies, we surmised that singlet oxygen generated through MB under light might contribute to both the beneficial and toxic effects of MB in vivo. We identified rose bengal (RB) that suppressed tau accumulation and ameliorated the behavioral deficits to a lesser extent than MB. Unlike MB, RB did not reduce the survival rate of flies. Our findings indicate that singlet oxygen generators with little toxicity may be suitable drug candidates for treating tauopathies.
|
| 巻・号 |
5
|
| ページ |
10821
|
| 公開日 |
2015-6-1
|
| DOI |
10.1038/srep10821
|
| PII |
srep10821
|
| PMID |
26027742
|
| PMC |
PMC4450544
|
| MeSH |
Animals
Animals, Genetically Modified
Autophagy
Behavior, Animal
Disease Models, Animal
Drosophila
Female
Humans
Male
Methylene Blue / pharmacology
Oxidative Stress
Singlet Oxygen / metabolism*
Solubility
Tauopathies / drug therapy
Tauopathies / metabolism*
tau Proteins / chemistry
tau Proteins / metabolism*
|
| IF |
3.998
|
| 引用数 |
9
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| ショウジョウバエ |
elav-GAL4 |
