RRC ID 3639
著者 Van Buskirk C, Sternberg PW.
タイトル Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans.
ジャーナル Nat Neurosci
Abstract The epidermal growth factor receptor (EGFR)/ErbB receptor tyrosine kinases regulate several aspects of development, including the development of the mammalian nervous system. ErbB signaling also has physiological effects on neuronal function, with influences on synaptic plasticity and daily cycles of activity. However, little is known about the effectors of EGFR activation in neurons. Here we show that EGF signaling has a nondevelopmental effect on behavior in Caenorhabditis elegans. Ectopic expression of the EGF-like ligand LIN-3 at any stage induces a reversible cessation of feeding and locomotion. These effects are mediated by neuronal EGFR (also called LET-23) and phospholipase C-gamma (PLC-gamma), diacylglycerol-binding proteins, and regulators of synaptic vesicle release. Activation of EGFR within a single neuron, ALA, is sufficient to induce a quiescent state. This pathway modulates the cessation of pharyngeal pumping and locomotion that normally occurs during the lethargus period that precedes larval molting. Our results reveal an evolutionarily conserved role for EGF signaling in the regulation of behavioral quiescence.
巻・号 10(10)
ページ 1300-7
公開日 2007-10-1
DOI 10.1038/nn1981
PII nn1981
PMID 17891142
MeSH Animals Animals, Genetically Modified Behavior, Animal / physiology* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism Caenorhabditis elegans Proteins / physiology* Enzyme Activation / drug effects Epidermal Growth Factor / physiology* ErbB Receptors / metabolism ErbB Receptors / physiology Green Fluorescent Proteins / metabolism Lethargy / genetics Lethargy / physiopathology Neurons / drug effects Neurons / metabolism Phospholipase C gamma / pharmacology Signal Transduction / physiology*
IF 20.071
引用数 129
WOS 分野 NEUROSCIENCES
リソース情報
線虫 tm1340