論文 - 詳細
RRC ID | 366 |
---|---|
著者 | Wei SY, Escudero LM, Yu F, Chang LH, Chen LY, Ho YH, Lin CM, Chou CS, Chia W, Modolell J, Hsu JC. |
タイトル | Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesion. |
ジャーナル | Dev Cell |
Abstract |
Echinoid is an immunoglobulin domain-containing transmembrane protein that modulates cell-cell signaling by Notch and the EGF receptors. We show that, in the Drosophila wing disc epithelium, Echinoid is a component of adherens junctions that cooperates with DE-Cadherin in cell adhesion. Echinoid and beta-catenin (a DE-Cadherin interacting protein) each possess a C-terminal PDZ domain binding motif that binds to Bazooka/PAR-3; these motifs redundantly position Bazooka to adherens junctions. Echinoid also links to actin filaments by binding to Canoe/AF-6/afadin. Moreover, interfaces between Echinoid- and Echinoid+ cells, like those between DE-Cadherin- and DE-Cadherin+ cells, are deficient in adherens junctions and form actin cables. These characteristics probably facilitate the strong sorting behavior of cells that lack either of these cell-adhesion molecules. Finally, cells lacking either Echinoid or DE-Cadherin accumulate a high density of the reciprocal protein, further suggesting that Echinoid and DE-Cadherin play similar and complementary roles in cell adhesion. |
巻・号 | 8(4) |
ページ | 493-504 |
公開日 | 2005-4-1 |
DOI | 10.1016/j.devcel.2005.03.015 |
PII | S1534-5807(05)00105-X |
PMID | 15809032 |
MeSH | Actins / metabolism Adherens Junctions / chemistry Adherens Junctions / metabolism* Animals Cadherins / genetics Cadherins / metabolism* Cell Adhesion / physiology* Cell Adhesion Molecules / genetics Cell Adhesion Molecules / metabolism* Cell Shape Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / anatomy & histology Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Drosophila melanogaster / metabolism Embryonic Structures / cytology Embryonic Structures / metabolism Intracellular Signaling Peptides and Proteins / genetics Intracellular Signaling Peptides and Proteins / metabolism Morphogenesis Protein Binding Protein Structure, Tertiary Recombinant Fusion Proteins / genetics Recombinant Fusion Proteins / metabolism Repressor Proteins / genetics Repressor Proteins / metabolism* Wings, Animal / cytology Wings, Animal / growth & development |
IF | 10.092 |
引用数 | 126 |
WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
リソース情報 | |
ショウジョウバエ |