RRC ID 36923
Author Ono A, Ito A, Suzuki T, Yamaguchi M, Kawabe Y, Kamihira M.
Title DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification.
Journal J. Biosci. Bioeng.
Abstract We constructed a DNA damage-responsive transgene expression system mediated by the p53 promoter. We incorporated a transactivation system to generate transcriptional amplification via a positive feedback loop. Higher levels of DNA damage-responsive transgene expression were observed when transactivation was active.
Volume 120(4)
Pages 463-6
Published 2015-10
DOI 10.1016/j.jbiosc.2015.02.009
PII S1389-1723(15)00087-0
PMID 25772439
MeSH 3T3 Cells Animals DNA Damage / drug effects DNA Damage / genetics* Feedback, Physiological / drug effects Humans Mice Mutagenicity Tests* Promoter Regions, Genetic / genetics* Tetracycline / pharmacology Transcription, Genetic / drug effects Transcription, Genetic / genetics* Transcriptional Activation / drug effects Transcriptional Activation / genetics* Transgenes / genetics* Tumor Suppressor Protein p53 / genetics* Up-Regulation / drug effects Up-Regulation / genetics
IF 2.015
Times Cited 0
WOS Category BIOTECHNOLOGY & APPLIED MICROBIOLOGY FOOD SCIENCE & TECHNOLOGY
Resource
Human and Animal Cells 293(RCB1637)