論文 - 詳細
| RRC ID | 37812 |
|---|---|
| 著者 | Wang X, Lam EK, Zhang J, Jin H, Sung JJ. |
| タイトル | MicroRNA-122a functions as a novel tumor suppressor downstream of adenomatous polyposis coli in gastrointestinal cancers. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Aberrant regulation of APC/beta-catenin signaling pathway is common in the pathogenesis of colorectal and other cancers. Targets regulated by APC/beta-catenin signaling pathway play crucial roles in cancer development. In the current study, we aimed to illustrate the influence of APC/beta-catenin signaling pathway on expression of microRNAs, one new group of players important to carcinogenesis. Restoration of APC function in colorectal cancer cells led to the deregulation of several cancer-related microRNAs, such as miR-122a which was recognized as the liver-specific microRNA. MiR-122a was down-regulated in gastrointestinal cancer cell lines as well as primary carcinoma tissues. Inhibition of miR-122a could reverse wild-type APC-induced growth inhibition of gastrointestinal cancer cells while miR-122a mimic inhibited cell growth. In summary, we identified some cancer-related microRNAs regulated by APC/beta-catenin signaling pathway. The down-regulation of miR-122a mediated by aberrant APC/beta-catenin signaling is important to the pathogenesis of gastrointestinal cancers. |
| 巻・号 | 387(2) |
| ページ | 376-80 |
| 公開日 | 2009-9-18 |
| DOI | 10.1016/j.bbrc.2009.07.034 |
| PII | S0006-291X(09)01380-1 |
| PMID | 19607815 |
| MeSH | Adenomatous Polyposis Coli / genetics* Carcinoma / genetics* Cell Line, Tumor Down-Regulation Gene Expression Profiling Gene Expression Regulation, Neoplastic* Genes, Tumor Suppressor* Humans MicroRNAs / genetics* beta Catenin / metabolism* |
| IF | 2.985 |
| 引用数 | 28 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |