論文 - 詳細
| RRC ID | 38382 |
|---|---|
| 著者 | Mellati A, Valizadeh Kiamahalleh M, Dai S, Bi J, Jin B, Zhang H. |
| タイトル | Influence of polymer molecular weight on the in vitro cytotoxicity of poly (N-isopropylacrylamide). |
| ジャーナル | Mater Sci Eng C Mater Biol Appl |
| Abstract |
Poly (N-isopropylacrylamide) (PNIPAAm) is a thermosensitive polymer with various biomedical applications. We examined molecular weight (MW)-dependent cytotoxicity of PNIPAAm. Our results indicated that low-MW PNIPAAm (degree of polymerization (DP)=35) is inherently toxic to cells. Moderate-MW PNIPAAms with their DP between 100 and 200 are non-cytotoxic. When cells are seeded on top of a polymer-coated surface, PNIPAAm with a higher MW (DP=400) shows non/low cytotoxicity, while when monolayer cells are exposed to the polymer solution, cell viability drops drastically. This may be due to lack of nutrient and oxygen rather than intrinsic toxicity of the polymer. |
| 巻・号 | 59 |
| ページ | 509-513 |
| 公開日 | 2016-2-1 |
| DOI | 10.1016/j.msec.2015.10.043 |
| PII | S0928-4931(15)30474-4 |
| PMID | 26652402 |
| MeSH | Acrylic Resins / chemistry* Acrylic Resins / toxicity* Cell Line Cell Survival / drug effects* Drug Delivery Systems HEK293 Cells HeLa Cells Humans Molecular Weight Temperature |
| IF | 5.88 |
| 引用数 | 13 |
| WOS 分野 | MATERIALS SCIENCE, BIOMATERIALS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 10T1/2(RCB0247) |