RRC ID 38679
著者 Ohkuma S, Shimizu S, Noto M, Sai Y, Kinoshita K, Tamura H.
タイトル Inhibition of cell growth by bafilomycin A1, a selective inhibitor of vacuolar H(+)-ATPase.
ジャーナル In Vitro Cell Dev Biol Anim
Abstract Bafilomycin A1, a potent selective inhibitor of vacuolar H(+)-ATPase, inhibited the growth of a variety of cultured cells dose-dependently, including golden hamster embryo and NIH-3T3 fibroblasts, whether or not they were transformed, and PC12 and HeLa cells. The concentration of bafilomycin A1 for 50% inhibition of cell growth ranged from 10 to 50 nM. The dose response was nearly parallel with that of the bafilomycin A1-induced lysosomal pH increase. The degree of pH increase for growth inhibition produced by bafilomycin A1 was similar to that produced by NH4Cl in which little difference was recognized in effect among cell types.
巻・号 29A(11)
ページ 862-6
公開日 1993-11-1
DOI 10.1007/BF02631364
PMID 8167902
MeSH 3T3 Cells Ammonium Chloride / pharmacology Animals Anti-Bacterial Agents / pharmacology* CHO Cells Cell Division / drug effects* Cell Line, Transformed Cricetinae HeLa Cells Humans Hydrogen-Ion Concentration Lysosomes / drug effects Lysosomes / metabolism Macrolides* Mice PC12 Cells Proton-Translocating ATPases / antagonists & inhibitors* Vacuoles / drug effects Vacuoles / enzymology*
IF 1.665
引用数 38
WOS 分野 CELL BIOLOGY DEVELOPMENTAL BIOLOGY
リソース情報
ヒト・動物細胞 PC-12(RCB0009)