| RRC ID |
38793
|
| Author |
Koseki T, Yamato K, Krajewski S, Reed JC, Tsujimoto Y, Nishihara T.
|
| Title |
Activin A-induced apoptosis is suppressed by BCL-2.
|
| Journal |
FEBS Lett
|
| Abstract |
Activin A, a member of TGF beta superfamily has various activities including induction of apoptosis in mammalian cells. However, it remains unknown how activin A induces cell death. To clarify this, we investigated the expression of BCL-2 and BAX, and the effect of BCL-2 overexpression on activin A-induced apoptosis in B cell hybridoma cell lines. The activin A-sensitive cell lines expressed BAX but not BCL-2 and that activin A did not increase BAX levels. Overexpression of human BCL-2 suppressed activin A-induced apoptosis in these cells. Thus, activin A has been shown to induce apoptosis by a BCL-2-inhibitable mechanism without activating BAX.
|
| Volume |
376(3)
|
| Pages |
247-50
|
| Published |
1995-12-4
|
| DOI |
10.1016/0014-5793(95)01290-7
|
| PII |
0014-5793(95)01290-7
|
| PMID |
7498552
|
| MeSH |
Activins
Animals
Apoptosis*
Cells, Cultured
DNA / metabolism
Humans
Hybridomas
Inhibins / physiology*
Mice
Proto-Oncogene Proteins / physiology*
Proto-Oncogene Proteins c-bcl-2
bcl-2-Associated X Protein
|
| IF |
3.057
|
| Times Cited |
24
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Human and Animal Cells |
M1(RCB0169)
U-937 DE-4(RCB0435) |
