RRC ID 39216
著者 Kabuyama Y, Hamaya M, Homma Y.
タイトル Wavelength specific activation of PI 3-kinase by UVB irradiation.
ジャーナル FEBS Lett
Abstract We investigated the effect of UVB irradiation on phospholipid metabolism using normal human diploid skin fibroblasts. When cells were exposed to monochromatic UV light, the intracellular PIP3 level was increased within 1 min in a wavelength-specific manner. The increase was most marked in the UVB range and was inhibited by a PI 3-kinase inhibitor, tyrosine kinase inhibitor, or antioxidant reagents. Furthermore, the decrease of cell viability induced by UVB irradiation was significantly blocked by wortmannin. These results suggest that PI 3-kinase activation is involved in novel cellular responses specific for UVB that lead to cell death.
巻・号 441(2)
ページ 297-301
公開日 1998-12-18
DOI 10.1016/s0014-5793(98)01565-8
PII S0014-5793(98)01565-8
PMID 9883903
MeSH Androstadienes / pharmacology Cell Survival / radiation effects Cells, Cultured Enzyme Activation / radiation effects Enzyme Inhibitors / pharmacology Humans Phosphatidylinositol 3-Kinases / metabolism* Phosphoinositide-3 Kinase Inhibitors Protein-Tyrosine Kinases / metabolism Reactive Oxygen Species Ultraviolet Rays* Wortmannin
IF 3.057
引用数 26
WOS 分野 BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
ヒト・動物細胞 NB1RGB(RCB0222)