論文 - 詳細
| RRC ID | 39330 |
|---|---|
| 著者 | Moriyama T, Kataoka H, Hamasuna R, Yoshida E, Sameshima T, Iseda T, Yokogami K, Nakano S, Koono M, Wakisaka S. |
| タイトル | Simultaneous up-regulation of urokinase-type plasminogen activator (uPA) and uPA receptor by hepatocyte growth factor/scatter factor in human glioma cells. |
| ジャーナル | Clin Exp Metastasis |
| Abstract |
Several lines of evidence indicate that hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, c-Met, may play an important role in progression of human glioma. In this study, effects of HGF/SF on urokinase- type plasminogen activator (uPA)-mediated proteolysis network were examined in c-Met-positive human glioma cell lines. Treatment of the glioma cells with various concentrations of HGF/SF resulted in an enhanced secretion of uPA proteins accompanying increased transcription of uPA mRNA in a dose dependent fashion. The levels of uPA receptor (uPAR) mRNAs were also elevated simultaneously upon HGF/SF stimulation, and the cell-surface associated uPA activity was also elevated by the treatment. Since concomitant expression of HGF and its receptor c-Met are frequently observed in malignant gliomas, these results suggest that HGF/SF participates in invasive process of malignant glioma cells not only by its motility-stimulating activity but also through enhanced degradation of the extracellular matrix induced by autocrine activation of uPA proteolysis network. |
| 巻・号 | 17(10) |
| ページ | 873-9 |
| 公開日 | 1999-1-1 |
| DOI | 10.1023/a:1006729611241 |
| PMID | 11089886 |
| MeSH | Central Nervous System Neoplasms / drug therapy Central Nervous System Neoplasms / metabolism* Glioma / drug therapy Glioma / metabolism* Hepatocyte Growth Factor / metabolism* Hepatocyte Growth Factor / pharmacology Humans Oligopeptides / metabolism Proto-Oncogene Proteins c-met / metabolism Receptors, Cell Surface / drug effects Receptors, Cell Surface / genetics Receptors, Cell Surface / metabolism* Receptors, Urokinase Plasminogen Activator Tumor Cells, Cultured Up-Regulation Urokinase-Type Plasminogen Activator / drug effects Urokinase-Type Plasminogen Activator / genetics Urokinase-Type Plasminogen Activator / metabolism* |
| IF | 3.027 |
| 引用数 | 24 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | U251(RCB0461) |