| RRC ID |
39542
|
| Author |
Yamaguchi T, Nagahama M, Itoh H, Hatsuzawa K, Tani K, Tagaya M.
|
| Title |
Regulation of the golgi structure by the alpha subunits of heterotrimeric G proteins.
|
| Journal |
FEBS Lett
|
| Abstract |
Disassembly of the Golgi apparatus is elicited by the action of nordihydroguaiaretic acid (NDGA) and this disassembly is prevented by the activation of heterotrimeric G proteins. In the present study we showed that overexpression of Galpha(z) or Galpha(i2) significantly suppresses the disassembly of the Golgi apparatus induced by NDGA. Overexpression of Gbeta(1)gamma(2), on the other hand, had no effect on NDGA-induced Golgi disassembly. Galpha(z) neither blocked Golgi disassembly induced by brefeldin A or nocodazole, nor interfered with protein transport, suggesting its specificity on the action of NDGA. Our results suggest that the alpha subunits of heterotrimeric G proteins are responsible for the maintenance of the Golgi structure.
|
| Volume |
470(1)
|
| Pages |
25-8
|
| Published |
2000-3-17
|
| DOI |
10.1016/s0014-5793(00)01284-9
|
| PII |
S0014-5793(00)01284-9
|
| PMID |
10722839
|
| MeSH |
Animals
Biological Transport
Brefeldin A / pharmacology
Cell Line
Cell Membrane / metabolism
Cyclooxygenase Inhibitors / pharmacology
Endoplasmic Reticulum / metabolism
GTP-Binding Protein alpha Subunit, Gi2
GTP-Binding Protein alpha Subunits*
GTP-Binding Protein alpha Subunits, Gi-Go*
Golgi Apparatus / drug effects
Golgi Apparatus / physiology*
Heterotrimeric GTP-Binding Proteins / biosynthesis
Heterotrimeric GTP-Binding Proteins / genetics
Heterotrimeric GTP-Binding Proteins / physiology*
Masoprocol / pharmacology
Nocodazole / pharmacology
Protein Synthesis Inhibitors / pharmacology
Proto-Oncogene Proteins / biosynthesis
Proto-Oncogene Proteins / genetics
Proto-Oncogene Proteins / physiology*
|
| IF |
3.057
|
| Times Cited |
12
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Human and Animal Cells |
|
