論文 - 詳細
| RRC ID | 39968 |
|---|---|
| 著者 | Abe T, Tamiya T, Ono Y, Salker AH, Akiyama K, Ohmoto T. |
| タイトル | Accumulation of cell cycle regulatory proteins, p21 and p27, induced after hyperthermia in human glioma cells. |
| ジャーナル | Int J Hyperthermia |
| Abstract |
It was investigated whether there was a relationship between p53 p21 and p27 induction pathways in the cellular response of glioma cells to hyperthermia. Two glioma cell lines were employed. A-172 cells had the wild-type of p53, and U251 cells had the mutant-type of p53. An adenovirus harbouring wild-type p53 was also used for the overexpression. The protein induction by hyperthermia was monitored by Western blot analysis. In U251 cells, the expression of wild-type p53 and hyperthermia had an additional cytotoxic effect, but did not affect A-172 cells. Significant p21 accumulation by hyperthermia was recognized in A-172 cells, and was also recognized in p53-transduced U251 cells. On the other hand, the accumulation of p27 by hyperthermia was not seen in A-172 or U251 cells, and the exogenous expression of p53 did not affect the accumulation of p27 by hyperthermia in U251 cells. These findings suggest that the p53-p21 pathway is involved in the signal transduction after hyperthermia, rather than the p27 pathway. |
| 巻・号 | 17(6) |
| ページ | 499-507 |
| 公開日 | 2001-1-1 |
| DOI | 10.1080/02656730110070219 |
| PMID | 11719966 |
| MeSH | Adenoviridae / genetics Cell Cycle Proteins / metabolism* Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p27 Cyclins / metabolism* Genes, p53 Genetic Vectors Glioma / genetics Glioma / metabolism* Glioma / therapy* Humans Hyperthermia, Induced* Lac Operon Signal Transduction Tumor Cells, Cultured Tumor Suppressor Protein p53 / metabolism Tumor Suppressor Proteins / metabolism* |
| IF | 3.574 |
| 引用数 | 8 |
| WOS 分野 | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | U251(RCB0461) |