論文 - 詳細
| RRC ID | 40039 |
|---|---|
| 著者 | Akagi K, Sarhan M, Sultan AR, Nishida H, Koie A, Nakayama T, Ueda H. |
| タイトル | A biological timer in the fat body comprising Blimp-1, βFtz-f1 and Shade regulates pupation timing in Drosophila melanogaster. |
| ジャーナル | Development |
| Abstract |
During the development of multicellular organisms, many events occur with precise timing. In Drosophila melanogaster, pupation occurs about 12 h after puparium formation and its timing is believed to be determined by the release of a steroid hormone, ecdysone (E), from the prothoracic gland. Here, we demonstrate that the ecdysone-20-monooxygenase Shade determines pupation timing by converting E to 20-hydroxyecdysone (20E) in the fat body, which is the organ that senses nutritional status. The timing of shade expression is determined by its transcriptional activator βFtz-f1. The βftz-f1 gene is activated after a decline in the expression of its transcriptional repressor Blimp-1, which is temporally expressed around puparium formation in response to a high titer of 20E. The expression level and stability of Blimp-1 is critical for the precise timing of pupation. Thus, we propose that Blimp-1 molecules function like sand in an hourglass in this precise developmental timer system. Furthermore, our data suggest that a biological advantage results from both the use of a transcriptional repressor for time determination and the association of developmental timing with nutritional status of the organism. |
| 巻・号 | 143(13) |
| ページ | 2410-6 |
| 公開日 | 2016-7-1 |
| DOI | 10.1242/dev.133595 |
| PII | dev.133595 |
| PMID | 27226323 |
| MeSH | Animals Biological Clocks* / drug effects Cytochrome P-450 Enzyme System / metabolism* DNA-Binding Proteins / metabolism* Drosophila Proteins / metabolism* Drosophila melanogaster / drug effects Drosophila melanogaster / genetics Drosophila melanogaster / growth & development* Drosophila melanogaster / metabolism* Ecdysterone / pharmacology Fat Body / drug effects Fat Body / metabolism* Gene Expression Regulation, Developmental / drug effects Models, Biological Protein Stability / drug effects Pupa / genetics Pupa / growth & development* Receptors, Steroid / metabolism* Repressor Proteins / metabolism* Time Factors |
| IF | 5.611 |
| 引用数 | 7 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 13478R-1 13478R-2 |