Reference - Detail
|Author||Kawamura A, Koshida S, Hijikata H, Sakaguchi T, Kondoh H, Takada S.|
|Title||Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites.|
Notch and fibroblast growth factor (FGF) signaling pathways have been implicated in the establishment of proper periodicity of vertebrate somites. Here, we show evidence that a Hes6-related hairy/Enhancer of split-related gene, her13.2, links FGF signaling to the Notch-regulated oscillation machinery in zebrafish. Expression of her13.2 is induced by FGF-soaked beads and decreased by an FGF signaling inhibitor. her13.2 is required for periodic repression of the Notch-regulated genes her1 and her7, and for proper somite segmentation. Furthermore, Her13.2 augments autorepression of her1 in association with Her1 protein. Therefore, FGF signaling appears to maintain the oscillation machinery by supplying a binding partner, Her13.2, for Her1.
|MeSH||Animals Basic Helix-Loop-Helix Transcription Factors Body Patterning / genetics Body Patterning / physiology* Fibroblast Growth Factors / metabolism Fibroblast Growth Factors / pharmacology Gene Expression Regulation, Developmental / genetics Gene Expression Regulation, Developmental / physiology* Signal Transduction / genetics Signal Transduction / physiology* Somites / metabolism* Transcription Factors / biosynthesis Transcription Factors / genetics Transcription Factors / metabolism* Zebrafish / embryology* Zebrafish / genetics Zebrafish Proteins / biosynthesis Zebrafish Proteins / genetics Zebrafish Proteins / metabolism*|
|WOS Category||GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY CELL BIOLOGY|