RRC ID 4112
Author McLean DL, Masino MA, Koh IY, Lindquist WB, Fetcho JR.
Title Continuous shifts in the active set of spinal interneurons during changes in locomotor speed.
Journal Nat. Neurosci.
Abstract The classic 'size principle' of motor control describes how increasingly forceful movements arise by the recruitment of motoneurons of progressively larger size and force output into the active pool. We explored the activity of pools of spinal interneurons in larval zebrafish and found that increases in swimming speed were not associated with the simple addition of cells to the active pool. Instead, the recruitment of interneurons at faster speeds was accompanied by the silencing of those driving movements at slower speeds. This silencing occurred both between and within classes of rhythmically active premotor excitatory interneurons. Thus, unlike motoneurons, there is a continuous shift in the set of cells driving the behavior, even though changes in the speed of the movements and the frequency of the motor pattern appear to be smoothly graded. We conclude that fundamentally different principles may underlie the recruitment of motoneuron and interneuron pools.
Volume 11(12)
Pages 1419-29
Published 2008-12
DOI 10.1038/nn.2225
PII nn.2225
PMID 18997790
PMC PMC2735137
MeSH Action Potentials / drug effects Action Potentials / physiology Adaptation, Physiological / physiology* Animals Behavior, Animal Dose-Response Relationship, Radiation Electric Stimulation / methods Electronic Data Processing / methods Excitatory Amino Acid Antagonists / pharmacology Fluorescent Dyes / metabolism Interneurons / physiology* Larva Motor Neurons / physiology Movement / physiology* Nerve Net / physiology Neural Inhibition / drug effects Neural Inhibition / physiology Neural Inhibition / radiation effects Patch-Clamp Techniques Periodicity Quinoxalines / pharmacology Recruitment, Neurophysiological / physiology Spinal Cord / cytology* Swimming / physiology* Synaptic Potentials / drug effects Synaptic Potentials / physiology Valine / analogs & derivatives Valine / pharmacology Zebrafish
IF 19.912
Times Cited 116
WOS Category NEUROSCIENCES
Resource
Zebrafish alx:GFP Tg(chx10:GFP)nns1?