RRC ID |
4112
|
著者 |
McLean DL, Masino MA, Koh IY, Lindquist WB, Fetcho JR.
|
タイトル |
Continuous shifts in the active set of spinal interneurons during changes in locomotor speed.
|
ジャーナル |
Nat Neurosci
|
Abstract |
The classic 'size principle' of motor control describes how increasingly forceful movements arise by the recruitment of motoneurons of progressively larger size and force output into the active pool. We explored the activity of pools of spinal interneurons in larval zebrafish and found that increases in swimming speed were not associated with the simple addition of cells to the active pool. Instead, the recruitment of interneurons at faster speeds was accompanied by the silencing of those driving movements at slower speeds. This silencing occurred both between and within classes of rhythmically active premotor excitatory interneurons. Thus, unlike motoneurons, there is a continuous shift in the set of cells driving the behavior, even though changes in the speed of the movements and the frequency of the motor pattern appear to be smoothly graded. We conclude that fundamentally different principles may underlie the recruitment of motoneuron and interneuron pools.
|
巻・号 |
11(12)
|
ページ |
1419-29
|
公開日 |
2008-12-1
|
DOI |
10.1038/nn.2225
|
PII |
nn.2225
|
PMID |
18997790
|
PMC |
PMC2735137
|
MeSH |
Action Potentials / drug effects
Action Potentials / physiology
Adaptation, Physiological / physiology*
Animals
Behavior, Animal
Dose-Response Relationship, Radiation
Electric Stimulation / methods
Electronic Data Processing / methods
Excitatory Amino Acid Antagonists / pharmacology
Fluorescent Dyes / metabolism
Interneurons / physiology*
Larva
Motor Neurons / physiology
Movement / physiology*
Nerve Net / physiology
Neural Inhibition / drug effects
Neural Inhibition / physiology
Neural Inhibition / radiation effects
Patch-Clamp Techniques
Periodicity
Quinoxalines / pharmacology
Recruitment, Neurophysiological / physiology
Spinal Cord / cytology*
Swimming / physiology*
Synaptic Potentials / drug effects
Synaptic Potentials / physiology
Valine / analogs & derivatives
Valine / pharmacology
Zebrafish
|
IF |
20.071
|
引用数 |
155
|
WOS 分野
|
NEUROSCIENCES
|
リソース情報 |
ゼブラフィッシュ |
alx:GFP
Tg(chx10:GFP)nns1? |