論文 - 詳細
| RRC ID | 41650 |
|---|---|
| 著者 | Wichterle H, Lieberam I, Porter JA, Jessell TM. |
| タイトル | Directed differentiation of embryonic stem cells into motor neurons. |
| ジャーナル | Cell |
| Abstract |
Inductive signals and transcription factors involved in motor neuron generation have been identified, raising the question of whether these developmental insights can be used to direct stem cells to a motor neuron fate. We show that developmentally relevant signaling factors can induce mouse embryonic stem (ES) cells to differentiate into spinal progenitor cells, and subsequently into motor neurons, through a pathway recapitulating that used in vivo. ES cell-derived motor neurons can populate the embryonic spinal cord, extend axons, and form synapses with target muscles. Thus, inductive signals involved in normal pathways of neurogenesis can direct ES cells to form specific classes of CNS neurons. |
| 巻・号 | 110(3) |
| ページ | 385-97 |
| 公開日 | 2002-8-9 |
| DOI | 10.1016/s0092-8674(02)00835-8 |
| PII | S0092867402008358 |
| PMID | 12176325 |
| MeSH | Animals Body Patterning / drug effects Body Patterning / physiology Cell Communication / physiology Cell Differentiation / drug effects Cell Differentiation / physiology* Cells, Cultured Chick Embryo Embryonic Induction / drug effects Embryonic Induction / physiology* Graft Survival / physiology Green Fluorescent Proteins Hedgehog Proteins Homeodomain Proteins / metabolism Indicators and Reagents Luminescent Proteins Mice Mice, Transgenic Motor Neurons / cytology Motor Neurons / drug effects Motor Neurons / metabolism* Signal Transduction / drug effects Signal Transduction / physiology* Spheroids, Cellular / cytology Spheroids, Cellular / drug effects Spheroids, Cellular / metabolism Spinal Cord / cytology Spinal Cord / embryology* Spinal Cord / metabolism Stem Cells / cytology Stem Cells / drug effects Stem Cells / metabolism* Trans-Activators / agonists Trans-Activators / metabolism Transcription Factors / metabolism Tretinoin / pharmacology |
| IF | 38.637 |
| 引用数 | 1194 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 125 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-G2/PA6(RCB1127) |