Reference - Detail
| RRC ID | 41692 |
|---|---|
| Author | Ikeguchi M, Kaibara N. |
| Title | survivin messenger RNA expression is a good prognostic biomarker for oesophageal carcinoma. |
| Journal | Br J Cancer |
| Abstract |
Oesophageal squamous cell carcinoma is one of the most malignant tumours. To identify patients with a high risk of recurrence of oesophageal squamous cell carcinoma, we investigated the prognostic significance of survivin mRNA expression in oesophageal squamous cell carcinoma, which has recently been reported to be a good marker for unfavourable prognosis in various tumours. Tumours and non-cancerous epitheliums adjacent to tumours were obtained by surgical resection from 57 patients with oesophageal squamous cell carcinoma. Expression levels of survivin and glyceraldehyde-3-phosphate dehydrogenase mRNA were analysed quantitatively by real-time reverse transcriptase polymerase chain reaction (RT-PCR). The survivin/glyceraldehyde-3-phosphate dehydrogenase ratios of tumours were higher than those of non-cancerous tissues (P=0.0003). Tumour-survivin/glyceraldehyde-3-phosphate dehydrogenase ratio did not correlate with histologic type, lymph node metastasis, and stage of tumours. In 53 surviving patients, the 5-year survival rate of 17 patients with high survivin mRNA expressed oesophageal squamous cell carcinoma (14.1%) was significantly poorer than that of 36 with low survivin mRNA expressed oesophageal squamous cell carcinoma (46.8%, P=0.0018). In these patients, tumour-survivin mRNA expression was recognised as a good marker of cancer recurrence independently from tumour stage. These findings indicate that survivin mRNA expression in oesophageal squamous cell carcinoma may be a good biomarker for identifying patients with high risk of cancer recurrence. |
| Volume | 87(8) |
| Pages | 883-7 |
| Published | 2002-10-7 |
| DOI | 10.1038/sj.bjc.6600546 |
| PII | 6600546 |
| PMID | 12373603 |
| PMC | PMC2376173 |
| MeSH | Aged Aged, 80 and over Antigens, Neoplasm / genetics* Antigens, Neoplasm / metabolism Biomarkers, Tumor / genetics* Biomarkers, Tumor / metabolism Carcinoma, Squamous Cell / metabolism* Carcinoma, Squamous Cell / secondary Carcinoma, Squamous Cell / surgery DNA Primers / chemistry Esophageal Neoplasms / metabolism* Esophageal Neoplasms / surgery Female Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) / metabolism Humans Immunoenzyme Techniques Inhibitor of Apoptosis Proteins Male Microtubule-Associated Proteins / genetics* Microtubule-Associated Proteins / metabolism Middle Aged Neoplasm Proteins Neoplasm Recurrence, Local / metabolism* Neoplasm Recurrence, Local / pathology Neoplasm Recurrence, Local / surgery Prognosis RNA, Messenger / biosynthesis* RNA, Neoplasm / genetics Reverse Transcriptase Polymerase Chain Reaction Survival Rate Survivin Tumor Cells, Cultured |
| IF | 5.791 |
| Times Cited | 77 |
| WOS Category | ONCOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | EC-GI-10(RCB0774) |